%0 Journal Article
%T A heterochronic genetic change from an EGFR mutation to an ALK rearrangement in a patient with lung adenocarcinoma: a case report
%A Shiroyama, Takayuki
%A Tamiya, Motohiro
%A Hayama, Manabu
%A Nishihara, Takashi
%A Nishida, Takuji
%A Tanaka, Ayako
%A Morishita, Naoko
%A Suzuki, Hidekazu
%A Okamoto, Norio
%A Kawahara, Kunimitsu
%A Hirashima, Tomonori
%J Journal of Thoracic Disease
%D 2016
%B 2016
%9 
%! A heterochronic genetic change from an EGFR mutation to an ALK rearrangement in a patient with lung adenocarcinoma: a case report
%K 
%X An 87-year-old man with postoperative recurrent lung adenocarcinoma was treated with gefitinib. At the beginning of treatment, surgically resected archived tumor tissue revealed a deletion in exon 19 of the EGFR gene, but no ALK gene rearrangement. After gefitinib treatment for 9 months, the disease progressed. Bronchoscopic rebiopsy was used to evaluate resistance mechanisms, and revealed lung adenocarcinoma with wild-type EGFR genes and a newly emerged  ALK gene rearrangement. Treatment was switched to alectinib and a partial response was achieved within 4 weeks. This is a rare case of heterochronic genetic change to an  ALK gene rearrangement in EGFR mutant lung adenocarcinoma.
%U https://jtd.amegroups.org/article/view/6996
%V 8
%N 5
%P E345-E348
%@ 2077-6624