@article{JTD7064,
author = {Panagiotis Tsirigotis and Spiros Chondropoulos and Konstantinos Gkirkas and Josef Meletiadis and Ioanna Dimopoulou},
title = {Balanced control of both hyper and hypo-inflammatory phases as a new treatment paradigm in sepsis},
journal = {Journal of Thoracic Disease},
volume = {8},
number = {5},
year = {2016},
keywords = {},
abstract = {The immune response of the host against invading pathogens is clinically manifested as sepsis. Sepsis is a complicated process characterized by distinct phases that usually occur in a sequential manner. The initial hyper-inflammation helps in elimination of the pathogen, but potentially may lead to excessive tissue injury. Hypo-inflammation helps in restoring immune homeostasis, but may lead to significant immune suppression and death from secondary infections if not appropriately controlled. Immune-modulating intervention in sepsis should be based on a balanced control of both the hyper and the hypo-inflammatory phase.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/7064}
}