%0 Journal Article
%T Effect of parecoxib combined with thoracic epidural analgesia on pain after thoracotomy
%A Ling, Xiao-Min
%A Fang, Fang
%A Zhang, Xiao-Guang
%A Ding, Ming
%A Liu, Qiu-A-Xue
%A Cang, Jing
%J Journal of Thoracic Disease
%D 2016
%B 2016
%9 
%! Effect of parecoxib combined with thoracic epidural analgesia on pain after thoracotomy
%K 
%X Background: Thoracotomy results in severe postoperative pain potentially leading to chronic pain. We investigated the potential benefits of intravenous parecoxib on postoperative analgesia combined with thoracic epidural analgesia (TEA).  Methods: Eighty-six patients undergoing thoracic surgery were randomized into two groups. Patient-controlled epidural analgesia (PCEA) was used until chest tubes were removed. Patients received parecoxib (group P) or placebo (group C) intravenously just 0.5 h before the operation and every 12 h after operation for 3 days. The intensity of pain was measured by using a visual analogue scale (VAS) and recorded at 2, 4, 8, 24, 48, 72 h after operation. The valid number of PCA, the side effects and the overall satisfaction to analgesic therapy in 72 h were recorded. Venous blood samples were taken before operation, the 1st and 3rd day after operation for plasma cortisol, adrenocorticotropic hormone (ACTH), interleukin-6 and tumor necrosis factor-α level. The occurrence of residual pain was recorded using telephone questionnaire 2 and 12 months after surgery.  Results: Postoperative pain scores at rest and on coughing were significantly lower with the less valid count of PCA and greater patient satisfaction in group P (P0.05). The occurrence of residual pain were 25% and 51.2% separately in group P and C 3 months postoperatively (P
%U https://jtd.amegroups.org/article/view/7081
%V 8
%N 5
%P 880-887
%@ 2077-6624