TY  - JOUR
AU  - Chen, Dehui
AU  - Xie, Na
AU  - Lin, Yuneng
AU  - Yang, Zifeng
AU  - Liu, Wenkuan
AU  - Wu, Shangzhi
AU  - Chen, Jingbin
AU  - Pan, Xiaoan
AU  - Yang, Shaolin
AU  - Cai, Yong
PY  - 2016
TI  - Diagnostic value of antineutrophil cytoplasmic antibodies in children with bronchiolitis obliterans
JF  - Journal of Thoracic Disease; Vol 8, No 6 (June 01, 2016): Journal of Thoracic Disease
Y2  - 2016
KW  - 
N2  - Background: Diagnosis of childhood bronchiolitis obliterans (BO) is difficult owing to non-specific clinical presentations and limited investigational options. There is a lack in established serum biomarkers for BO. While the diagnostic value of antineutrophil cytoplasmic antibodies (ANCAs) has been discussed, little is known about this in BO. We aimed to investigate the serological profiles of ANCAs against myeloperoxidase (MPO-ANCA) and proteinase-3 (PR3-ANCA) in BO and acute pneumonia.  Methods: In this study, 42 BO children (BO group) and 43 with mild acute pneumonia (pneumonia group) were included, based on rigorous diagnostic criteria and additional constraints for minimizing selection bias. Serum MPO-ANCA and PR3-ANCA levels were measured on the first (baseline) and the last day of hospitalization (on discharge) by enzyme linked immunosorbent assay.  Results: Although the BO children had a longer hospital stay, the overall rate of positivity (≥180 AAU/mL) and median serum level of MPO-ANCA were higher in the BO group compared with the pneumonia group, either at baseline (69.1% vs. 9.3%, 292.00 vs. 104.75 AAU/mL, both P
UR  - https://jtd.amegroups.org/article/view/7633