TY  - JOUR
AU  - Spits, Menno
AU  - Neefjes, Jacques
PY  - 2016
TI  - Immunoproteasomes and immunotherapy—a smoking gun for lung cancer?
JF  - Journal of Thoracic Disease; Vol 8, No 7 (July 05, 2016): Journal of Thoracic Disease
Y2  - 2016
KW  - 
N2  - Lung cancer is the second most prevalent cancer in both women and men with some 221,200 new cases and 158,040 deaths reported in 2015. Almost 90% of these are non-small cell lung cancer (NSCLC) and these patients have a very poor prognosis. Recently a new treatment option for NSCLC appeared that strongly improved treatment responses—immunotherapy. Here we review the various forms of immunotherapy and how immune modification of proteasomes in lung cancer may support the immune system in controlling NSCLC. These immunoproteasomes then support recognition of NSCLC and may act as a biomarker for selecting responding patients to immunotherapy.
UR  - https://jtd.amegroups.org/article/view/7734