@article{JTD8147,
author = {Zhi-Gang Cao and Yan-Ni Huang and Ling Yao and Yi-Rong Liu and Xin Hu and Yi-Feng Hou and Zhi-Min Shao},
title = {Positive expression of miR-361-5p indicates better prognosis for breast cancer patients},
journal = {Journal of Thoracic Disease},
volume = {8},
number = {7},
year = {2016},
keywords = {},
abstract = {Background: MicroRNA-361-5p (miR-361-5p) has been reported to be tumor suppressor in colorectal, gastric and prostate cancer, but as an oncogene in cervical cancer. No previous research has focused on the expression of miR-361-5p and its exact prognostic role in breast cancer (BC).
Methods: In this study, a tissue microarray (TMA)-based miRNA detection in situ hybridization (ISH) with LNA probe was used to detect miR-361-5p expression in 375 BC tissue. The expression level of miR-361-5p in BC and its potential prognostic value was investigated.
Results: Positive miR-361-5p staining was observed in 78.7% (N=295; 78.7% positive, 21.3% negative) in the 375 cases. The clinical outcome of patients with positive miR-361-5p expression [median disease-free survival (DFS) time 95.52 months] was significantly better than that of patients (median DFS time 82.33 months) with negative miR-361-5p expression (P=0.002). Moreover, the prognostic value of miR-361-5p was most significant among patients with triple-negative breast cancer (TNBC) for DFS (P=0.004).
Conclusions: These results indicated that miR-361-5p expression is an independent predictive factor for better prognosis in BC.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/8147}
}