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The analysis of components that lead to increased work of breathing in chronic obstructive pulmonary disease patients

   
@article{JTD8763,
	author = {Sibei Chen and Ying Li and Zeguang Zheng and Qun Luo and Rongchang Chen},
	title = {The analysis of components that lead to increased work of breathing in chronic obstructive pulmonary disease patients},
	journal = {Journal of Thoracic Disease},
	volume = {8},
	number = {8},
	year = {2016},
	keywords = {},
	abstract = {Background: This study is to explore the components and related mechanism responsible for the increase of work of breathing (WB) in chronic obstructive pulmonary disease (COPD) patients. 
Methods: Eight COPD patients and eight healthy volunteers were recruited in the study. The rebreathing method was used to increase end-tidal CO2 partial pressure (PetCO2) and stimulate the increase in ventilation (VE). The increase in VE, WB, and changes in the compositions of WB were observed and analyzed. The WB and its components were calculated using the Campbell diagram. 
Results: The inspiratory work (Wi) of breathing, a major component of total work of breathing (Wtot), in the COPD group was significantly higher than the control group during quiet breathing (P},
	issn = {2077-6624},	url = {https://jtd.amegroups.org/article/view/8763}
}