@article{JTD924,
author = {Gholamali Godazandeh and Nasim Haji Qasemi and Mohammad Saghafi and Meisam Mortazian and Pouya Tayebi},
title = {Pleurodesis with povidone-iodine, as an effective procedure in management of patients with malignant pleural effusion},
journal = {Journal of Thoracic Disease},
volume = {5},
number = {2},
year = {2013},
keywords = {},
abstract = {Objective: Overtime, malignant pleural effusion (MPE) arises in advanced-stages of malignancies and frequently heralds a poor prognosis. If the underlying malignancy is chemo sensitive, systemic chemotherapy may control pleural effusion. A common method for the management of the patients with refractory MPE is pleurodesis through the introduction of sclerosing agents such as talc, bleomycin administered/instilled into the pleural cavity. However, the present prospective study aimed to investigate the efficacy and safety of pleurodesis with povidone-iodine (Betadine) in patients with MPE admitted in Sari General Hospital during 2008-2011.
Methods: Thirty-six patients who underwent pleurodesis by instilling povidone-iodine through a thoracostomy tube, as a bedside procedure were enrolled in the study. For evaluating the effect of povidone-iodine on thyroid gland, the authors measured the thyroid function tests before and after the pleurodesis at 1 week.
Results: The response to this procedure was complete in 26 patients (72.2%) and partial in 7 patients (19.4%). Treatment failure was displayed in 3 patients (8.3%). The overall success rate was 91.6%. In post-procedure, the most common complaints of the patients were pain (35.9%) followed by dyspnea, burning and fever. Povidone-iodine does not affect on thyroid function tests.
Conclusions: Povidone-iodine is an effective, inexpensive, safe and feasible agent for chemical pleurodesis in management of MPE.},
issn = {2077-6624}, url = {https://jtd.amegroups.org/article/view/924}
}