In strict cooperation with The Journal of Thoracic Disease Editorial Board, I decided to dedicate a special issue of the journal in order to improve the knowledge on the treatment of such controversial tumors. The selection of the review articles covers most of the aspects of what surgeons are called to face when they have to treat a patient with an advanced LC, and have been written by world-renown experts in this field. The issues of N2 diseases, tumors involving the chest wall, the vertebral bodies or the mediastinum, bronchial, arterial and carinal sleeve resections and chest wall reconstruction after extended resections are covered by this supplement.
