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JTD Chinese Edition more


肺持续性漏气和术中出血的诊治是胸外科手术中常见的挑战之一。 More >>


中国香港的胸外科早在20世纪50年代还是一个新兴的亚专科,主要关注于非解剖性肺切除术和肺结核的开胸治疗。 More >>


中国台湾位于南海以北,距大陆东南沿海约180公里,总面积3.6万平方公里... More >>

Air Pollution more

Age modification of ozone associations with cardiovascular disease risk in adults: a potential role for soluble P-selectin and blood pressure

Drew B. Day, Merlise A. Clyde, Jianbang Xiang, Feng Li, Xiaoxing Cui, Jinhan Mo, Jicheng Gong, Charl... More >>

Assessment of a respiratory face mask for capturing air pollutants
and pathogens including human influenza and rhinoviruses

S. Steve Zhou, Salimatu Lukula, Cory Chiossone, Raymond W. Nims, Donna B. Suchmann, M. Khalid Ijaz More >>

Relationship between free and total malondialdehyde, a well-established marker of oxidative stress, in various types of human biospecimens

Xiaoxing Cui, Jicheng Gong, Hailong Han, Linchen He, Yanbo Teng, Teresa Tetley, Rudy Sinharay, Kian ... More >>

Cough Section more

Clinical Practice Guidelines for Diagnosis and Management of Cough—Chinese Thoracic Society (CTS) Asthma Consortium

Kefang Lai, Huahao Shen, Xin Zhou, Zhongmin Qiu, Shaoxi Cai, Kewu Huang, Qiuping Wang, Changzheng Wa... More >>

Cough frequency monitors: can they discriminate patient from environmental coughs?

Stefan T. Kulnik, Natalie M. Williams, Lalit Kalra, John Moxham, Surinder S. Birring More >>


Journal of Thoracic Disease is endorsed by: The International COPD Coalition

The International COPD Coalition

The Brazilian Society of Thoracic Surgery (SBCT)

The Brazilian Society of Thoracic Surgery (SBCT)

The Italian Society of Thoracic Surgery (SICT)

The Italian Society of Thoracic Surgery (SICT)

The Italian VATS Group

The Italian VATS Group

The Global Alliance against Chronic Respiratory Diseases (GARD)

The Global Alliance against Chronic Respiratory Diseases (GARD)

The Hong Kong Society of Endosonography

The Hong Kong Society of Endosonography

Original Article

Prevalence of carotid artery stenosis and intra-cranial lesions in patients with aortic arch aneurysm and its association with intraoperative regional cerebral oxygen saturation and postoperative neurological outcomes
Daijiro Hori, Takahiro Yamamoto, Naoyuki Kimura, Atsushi Yamaguchi
Thoracic cavity remodeling and pulmonary function change after chest wall resection
Seon Yong Bae, Ji Hyeon Park, Bubse Na, Kwon Joong Na, Samina Park, In Kyu Park, Chang Hyun Kang, Young Tae Kim
Intraprocedural computed tomography-guided navigation with ventilatory strategy for atelectasis (ICNVA): a modified electromagnetic navigation bronchoscopy
Shaohua Dai, Guoqiu Xu, Zhiguo Chen, Jian Tang
Network pharmacology to explore the mechanism of traditional Chinese medicine in the treatment of ground glass nodules
Feng Wang, Cui-Lian Mo, Ming Lu, Xiao-Long Deng, Jia-Ying Luo
Indeterminate pulmonary nodules and prior malignancy: survival and recurrence after surgery in newly diagnosed stage I non-small cell lung cancer
José Franco, Genaro Galán, Elvira Bondía, Irene Pastor, Andrea Calderón, Amelia Insa, Miguel Á. Mollá, Paloma Martín-Martorell, Juan A. Carbonell, Jaime Signes-Costa
Systemic immune-inflammation index in predicting hospitalized bronchiectasis exacerbation risks and disease severity
Wang Chun Kwok, Terence Chi Chun Tam, David Chi Leung Lam, Mary Sau Man Ip, James Chung Man Ho
Multimodal prehabilitation in patients with non-small cell lung cancer: a feasibility study
David W. G. ten Cate, Rosaline van den Berg, Maaike Scholten-Bakker, Charlotte J. L. Molenaar, Erik M. von Meyenfeldt, Gerrit D. Slooter, Frank J. C. van den Broek, Geertruid M. H. Marres
Pediatric vascular ring outcomes for surgically repaired vs. unoperated children: a single-center experience
Houdaïfa Ajdaa, Karlien Carbonez, Jelena Hubrechts, Catherine Barrea, Geoffroy de Beco, Mona Momeni, Alain J. Poncelet
Prevalence of concomitant aortic disease and lung cancer: an exploratory study
Edoardo Pasqui, Luca Luzzi, Elisa Lazzeri, Giulia Casilli, Giulia Ferrante, Chiara Catelli, Piero Paladini, Gianmarco de Donato
Integrated endoscopic treatment of primitive unresectable tracheal tumor: the INTACT retrospective cohort study
Alessandro Marchioni, Linda Manicardi, Roberto Tonelli, Luca Tabbì, Dario Andrisani, Antonio Lamesta, Anna Mocellin, Giulia Bruzzi, Gaia Cappiello, Alessandro Andreani, Francesco Mattioli, Pierluigi Filosso, Enrico Clini
Different treatment modalities on the prognosis of patients with stage I–IIIa small cell lung cancer: a population based study
Fangjun Chen, Zihan Wang, Xing Gu, Yihong Ni, Guangliang Qiang
The inciting factor for bradycardia in COVID-19 patients: a potential harm of steroid treatment
Misa Ogiwara, Hiroaki Ihara, Yuki Muto, Manami Haba, Hiroki Nakazawa, Saori Hotta, Hitomi Jo, Noriko Hayama, Yuichiro Honma, Sakuo Hoshi, Mitsuhiro Fujii, Kazuhisa Takahashi
Intraoperative changes in upper extremity perfusion index after thoracic paravertebral and intertransverse process block in patients undergoing lung resection surgery
Chahyun Oh, Sun Yeul Lee, Soomin Lee, Jiyong Lee, Sujin Baek, Myungjong Shin, Yooyoung Chong, Min-Woong Kang, Chaeseong Lim, Sung Joon Han, Boohwi Hong
Presurgical invasive mediastinal staging in lung cancer, unexpected N2 and long-term survival: a registry-based study with data from the Spanish group for video-assisted thoracic surgery
Iker López, Borja Aguinagalde, Iratxe Urreta, Iñigo Royo, Sergio Bolufer, Laura Sánchez, Jon Zabaleta, Arantza Fernández-Monge, Raúl Embún; on behalf of the Spanish Group for Video-Assisted Thoracic Surgery (GEVATS)
Thoracoscopic surgery for rare congenital pulmonary airway malformations in adults: a decade of retrospective study
Yuqing Zhao, Huimin Jia
Differentiating inflammatory and malignant pulmonary lesions on 3T lung MRI with radiomics of apparent diffusion coefficient maps and T2w derived radiomic feature maps
Laura J. Jensen, Damon Kim, Thomas Elgeti, Ingo G. Steffen, Lars-Arne Schaafs, Bernd Hamm, Sebastian N. Nagel
Factors associated with incomplete resection for large, locally invasive non-small cell lung cancer
Whitney S. Brandt, Zhizhou Yang, Brendan T. Heiden, Pamela P. Samson, Daniel Morgensztern, Saiama N. Waqar, Bryan F. Meyers, Ruben G. Nava, G. Alexander Patterson, Benjamin D. Kozower, Varun Puri
Comparison of high-flow nasal cannula with conventional oxygen therapy for preventing postoperative hypoxemia in patients with lung resection surgery: a systematic review and meta-analysis
Xingxing Zhang, Xiaoqing Li, Yang Li, Wenchun Wang, Yun Yu
The safety and feasibility of mini-invasive Bentall surgery via right anterior mini-thoracotomy
Xin He, Fengwei Guo, Jing Li, Yongxin Li, Yang Yan
Feasibility of the modified mini-bronchoalveolar lavage techniques using a nasogastric suction catheter and polytetrafluoroethylene bronchoscopic suction catheter in diagnosing bilateral pneumonia: a pilot study
Phongsaphat Pojpanichphong, Nadwipa Yuangtrakul
Regional trends in diagnosis of advanced lung cancer in Michigan over 33 years
Hollis E. Hutchings, Sue C. Grady, Qiong Zhang, Erik Schwarze, Andrew Popoff, Kamil Khanipov, Ikenna C. Okereke
Clinical characteristics and survival of esophageal cancer patients: annual report of the surgical treatment in Shanghai Chest Hospital, 2017
Chang Yuan, Xiaolu Wu, Yuxin Yang, Zhichao Liu, Yifeng Sun, Xufeng Guo, Bin Li, Rong Hua, Yang Yang, Teng Mao, Hong Zhang, Yuchen Su, Chunguang Li, Shanshan Geng, Zhigang Li
Clinical outcomes and staff satisfaction after adoption of digital chest drainage system for minimally invasive lung resections
Benjamin A. Palleiko, Anupama Singh, Christopher Strader, Tanmay Patil, Allison Crawford, Isabel Emmerick, Feiran Lou, Karl Uy, Mark W. Maxfield
Prognostic impact of ground-glass opacity components in lung cancer with lymph node metastasis
Satoru Tamagawa, Masayuki Nakao, Katsunori Oikado, Yoshinao Sato, Kohei Hashimoto, Junji Ichinose, Yosuke Matsuura, Sakae Okumura, Yukitoshi Satoh, Mingyon Mun
The efficacy and safety of hydroxychloroquine for COVID-19 prophylaxis and clinical assessment: an updated meta-analysis of randomized trials
Xudong Han, Wei Shi, Ya Yang
Association between anion gap and the 30-day mortality of patients with ventilator-associated pneumonia: a study of the MIMIC-III database
Hui Yu, Sheng Chen
mTOR inhibitors after lung transplantation: a real-life experience
Katja Schmucki, Thomas Gaisl, Patrick Hofmann, René Hage, Carolin Steinack, Thomas Hans Fehr, Silvia Ulrich, Macé M. Schuurmans
Airway stent intervention in a high-volume center: safe procedures and educational perspectives
Takuya Watanabe, Masayuki Tanahashi, Eriko Suzuki, Naoko Yoshii, Takuya Kohama, Kensuke Iguchi, Suiha Takeuchi, Minori Nakamura, Takumi Endo
CT findings, prognosis, and follow-up of pulmonary artery periadventitial hematoma with aortic dissection: a retrospective single-center study
Hirofumi Koike, Eijun Sueyoshi, Chika Somagawa, Hiroki Nagayama, Ryo Toya
Non-intubated bronchoscopic tracheobronchial surgeries with electroencephalogram-monitored intravenous anesthesia: feasibility and outcomes
Yu Fang, Ching-Kai Lin, Zong-Han Yao, Hung-Jen Fan, Ya-Jung Cheng
Erythromycin regulates peroxisome proliferator-activated receptor γ to ameliorate cigarette smoke-induced oxidative stress in macrophages
Qiqi Li, Yunjie Wei, Yanlin Wei, Kaiye He, Guopeng Liao, Lingyun Cheng, Meihua Li
Establishment and validation of a clinicopathological prediction model for postoperative recurrence of stage IA lung adenocarcinoma
Xin Zhang, Jie Yang, Shining Li, Yong Ao, Leqi Zhong, Xinyu Liu, Kongjia Luo, Yi Hu
Causal relationship between renal function and risk of esophageal cancer: insights from Mendelian randomization
Yi Shi, Qingyue Zeng, Shuangqing Li, Di Deng
Comparison of cardiorespiratory parameters between 6-minute walk test and 1-minute sit to stand test in young adults with post-COVID-19: follow-up 3 months
Patchareeya Amput, Puttipong Poncumhak, Saisunee Konsanit, Sirima Wongphon
Early chest tube removal within 6 hours after thoracic surgery results in improved postoperative prognosis and no adverse effects
Takahiro Homma, Hisashi Saji, Yoshifumi Shimada, Keitaro Tanabe, Koji Kojima, Hideki Marushima, Tomoyuki Miyazawa, Hiroyuki Kimura, Hiroki Sakai, Kanji Otsubo, Takayuki Hatakeyama, Tomoshi Tsuchiya
Interest of the Leicester Cough Questionnaire in predicting postoperatives complications after lung resection: LCQ-SURGE
Caroline Corbice, André Gillibert, François-Régis Sarhan, Mathieu Sarsam, Jean Selim, Benjamin Bottet, Jean-Marc Baste, Fairuz Boujibar
Risk factors for the recurrence of left atrioventricular valvular regurgitation after surgical repair of partial and transitional atrioventricular septal defect
Jiatong Li, Tan Liu, Yuji Xie, Xin Zhang, Jie Liu, Ruize Zhang, Yun Yang, Shuangshuang Zhu, Yali Yang, Jing Wang, Li Zhang, Qing Lv, Lin He, Lingyun Fang, Wenqian Wu, He Li, Yuman Li, Mingxing Xie
Cryptogenic organizing pneumonia: clinical outcomes of 60 consecutive cases
Yoshihiko Taniguchi, Toru Arai, Taisuke Tsuji, Chikatoshi Sugimoto, Kazunobu Tachibana, Masanori Akira, Yoshikazu Inoue
Diagnostic value and safety of medical thoracoscopy in undiagnosed pleural effusions—a prospective observational cohort study
Ken Junyang Goh, Carrie Kah-Lai Leong, Si Ling Young, Brian Lee Wei Chua, Jane Jing Yi Wong, Ivana Gilcrist Chiew Sian Phua, Wen Ting Lim, Devanand Anantham, Qiao Li Tan
Integrative bioinformatics approach for identifying key genes and potential therapeutic targets in the concurrent manifestation of hypertrophic cardiomyopathy and pulmonary hypertension
Xi Zheng, Chenyang Zhang, Tao Yang, Zhanyang Luo, Junyi Xia, Weibin Tian, Juan Shao, Hu Zhang, Jingru Gong, Xuhui Bao
Specific sequelae symptoms of COVID-19 of Omicron variant in comparison with non-COVID-19 patients: a retrospective cohort study in Japan
Takahiro Omori, Mariko Hanafusa, Nobuyuki Kondo, Yasunari Miyazaki, Shusho Okada, Takeo Fujiwara, Jin Kuramochi
Complement activation is associated with right ventricular dysfunction and the severity of pulmonary embolism: links with prothrombotic state
Paweł Rostoff, Michał Ząbczyk, Joanna Natorska, Anetta Undas
Comparison of frailty indexes as predictors of clinical outcomes after major thoracic surgery
Sara Parini, Danila Azzolina, Fabio Massera, Christian Garlisi, Esther Papalia, Guido Baietto, Giulia Bora, Maria Giovanna Mastromarino, Michela Barini, Enrico Ruffini, Alessandro Carriero, Ottavio Rena
Anesthetic predictors for postoperative pneumonia in patients with non-small cell lung cancer
Wenzhi Zhu, Liping Zhu, Shuang Li, Xiaoyi Wang, Hongyu Tan
Value of computed tomography radiomics combined with inflammation indices in predicting the efficacy of immunotherapy in patients with locally advanced and metastatic non-small cell lung cancer
Hancheng Shao, Jun Zhu, Liang Shi, Jie Yao, Yuxuan Wang, Chonggang Ma, Andrzej Swierniak, Bin Ni
The clinical, radiological, postoperative pathological, and genetic features of nodular lung adenocarcinoma: a real-world single-center data
Weixiang Zhong, Wenshu Zhang, Lei Dai, Mingwu Chen
Increasing serum complement component 1q is associated with worse prognosis in advanced non-small cell lung cancer treated with immune checkpoint inhibitors: a single-center, retrospective study
Jiazhuo Tang, Yang Fu, Yuxiao Song, Jiaxin Yin, Jun Wang, Hugo Arasanz, Bicheng Zhang
Clinical outcomes of the type II hybrid procedure for the repair of extensive aortic arch pathology
Yuan Xue, Yeting Lou, Xiaomeng Wang, Shipan Wang, Yue Shi, Duanduan Chen, Giovanni Mariscalco, Ioannis Dimarakis, Haiyang Li, Hongjia Zhang
Effectiveness and safety of a novel modified homemade snare in retrograde percutaneous coronary intervention for chronic total occlusion lesions: a retrospective cohort study
Tao Zhang, Yuchen Zhang, Tingting Feng, Lin Zhao
Diagnostic value of contrast-enhanced ultrasonography for patent foramen ovale detection
Kun Xu, Xiaoguang Tian, Meifang Hao, Yiying Li, Jingxuan Zhang, Randolph H. L. Wong, Adrianna Othmani, Quanbin Zhang
Analysis of related factors and treatment effect of chylothorax after lung surgery
Xingyu Zhu, Xiangwei Feng, Zhengwei Huang, Wangjue Xu, Aotian Guo, Jingwei Xu, Zhao Chen, Tao Shen, Jiayu Zhou, Zhengfu He
Development and validation of a self-attention network-based algorithm to detect mediastinal lesions on computed tomography images
Sizhu Wu, Shengyu Liu, Ming Zhong, Erik R. de Loos, Marc Hartert, Álvaro Fuentes-Martín, Alessandra Lenzini, Dejian Wang, Qing Qian
Comparative outcomes of video-assisted thoracoscopic surgery versus open surgery for bronchogenic cysts in adults: a retrospective cohort study
Guowen Wang, Xiang Ji, Chunyu Yao, Yiyao Jiang, Lin Wang, Chuankui Li, Tao Tao, Qicai Li, Yifan Yang, Lixiang Li, Jae Jun Kim, Gregor J. Kocher, Angelo Carretta, Savvas Lampridis, Panagiotis T. Tasoudis, Zuyi Wang, Huaguang Pan, Hanlin Fang, Renquan Zhang
Postoperative follow-up of 221 patients with infective endocarditis from Gaoligong mountain area of Yunnan in China: a retrospective, single-center, observational cohort study
Hua Li, Yaxiong Li, Zheng Jia, Le Ren, Francesco Nappi, Xiao Ma, Yu Jiang, Shen Han
Somatic KMT2D loss-of-function mutations in lung squamous cell carcinoma: a single-center cohort study
Zekui Fang, Xiping Wu, Li Xiao, Chunli Wang, Yanyan Zhao, Qingchao Zhang, Paola Anna Jablonska, Alonso La Rosa, Wolfram C. M. Dempke, Muhammad Furqan, Huizhen Fan
Performance verification of a biochemical detection system for hydrothorax and ascites and clinical diagnostic accuracy evaluation of exudate and tuberculous effusion
Junyuan Huang, Pinning Feng, Yongjiang Chen, Xi Li, Iyare Izevbaye, Weiguo Lu, Yingchun Zhou

Study Protocol

Treatment rationale and protocol design: an investigator-initiated phase II study of combination treatment of nivolumab and TM5614, a PAI-1 inhibitor for previously treated patients with non-small cell lung cancer
Takeshi Masuda, Taizo Hirata, Tomohiro Sakamoto, Yukari Tsubata, Eiki Ichihara, Toshiyuki Kozuki, Hiroyasu Shoda, Masanori Motonaga, Takako Yoshida, Miki Fukutani, Kazue Tsuji-Takayama, Atsushi Tamura, Harunobu Amagase, Hideki Fujihara, Gaku Aoki, Tomoyuki Akita, Yasushi Orihashi, Toshio Miyata, Noboru Hattori

Review Article

Application of nanomaterials in heart transplantation: a narrative review
Huaiyu Jiang, Qiang Zhao, Xiaofeng Ye
Clinically important pulmonary vascular variations: a narrative review
Maciej T. Pawlica, Karolina Buchajska, Zuzanna Gabrysz, Marcin M. Cackowski, Michał Dziedzic, Tadeusz M. Orłowski, Dariusz A. Dziedzic
Post-thoracotomy pain syndrome in the era of minimally invasive thoracic surgery
Takuro Miyazaki, Ryoichiro Doi, Keitaro Matsumoto
Lung abscess: the non-conservative management: a narrative review
Walid Hadid, Giulia Maria Stella, Ashish P. Maskey, Rabih I. Bechara, Shaheen Islam
Thoracic manifestations and respiratory function alterations in axial spondyloarthritis and newest possibilities of ultrasound to detect changes in diaphragm—a narrative review
Hana Skala Kavanagh, Jan Aksentijević, Frane Grubišić, Simeon Grazio, Marija Gomerčić Palčić
A narrative review of theophylline: is there still a place for an old friend?
Martin Scurek, Kristian Brat
Surgical treatment of atrial fibrillation in mitral valve surgery: a narrative review
Yang Zou, Ning Yang, Fangbao Ding, Yingman Wang, Ju Mei, Zhaolei Jiang
Development of neuromodulation for atrial fibrillation: a narrative review
Ning Yang, Yang Zou, Bohan Wen, Yingman Wang, Ju Mei, Zhaolei Jiang
Management of soft tissue sarcomas of the chest wall: a comprehensive overview
Lori M. van Roozendaal, Joanna W. A. M. Bosmans, Jean H. T. Daemen, Aimee J. P. M. Franssen, James van Bastelaar, Sanne M. E. Engelen, Kristien B. M. I. Keymeulen, Wolfgang W. Schmidt Aguiar, Jose Ribas Milanez de Campos, Karel W. E. Hulsewé, Yvonne L. J. Vissers, Erik R. de Loos

Editorial Commentary

Wedge resection vs. segmentectomy: when is each acceptable in early-stage lung adenocarcinoma?
Palina Woodhouse, Eric L. Grogan
Who are the real candidates for wedge resection of lung cancer?
Takayuki Kosaka, Seshiru Nakazawa, Takashi Ibe, Ken Shirabe
Pure ground-glass opacities (GGO) lung adenocarcinoma: surgical resection is curative
Kevin X. Huang, Barry C. Gibney
Striking a balance when operating for acute type A aortic dissection
Viswajit Kandula, Adham Elmously, Thomas F. X. O’Donnell, Virendra I. Patel, Hiroo Takayama
Let’s think outside of the box
Paula Duarte D’Ambrosio, Juliana Ferreira, C. Isabela Silva Muller, Paula Antonia Ugalde Figueroa
Anatomical partial lobectomy is a minimally invasive and precise procedure: beware of overuse
Junji Ichinose, Ayumi Suzuki, Yosuke Matsuura, Masayuki Nakao, Sakae Okumura, Mingyon Mun
The evolving field of sublobar resection: in search of the optimal operation or the optimal definition
Luis J. Herrera, Kojo Dadzie

Original Article

Nonintubated thoracoscopic lung resection: a 3-year experience with 285 cases in a single institution
Ke-Cheng Chen, Ya-Jung Cheng, Ming-Hui Hung, Yu-Ding Tseng, Jin-Shing Chen
Delays in the diagnosis of lung cancer
Peter M Ellis, Rachel Vandermeer
The diagnostic utility of endobronchial ultrasonography with a guide sheath and tomosynthesis images for ground glass opacity pulmonary lesions
Takehiro Izumo, Shinji Sasada, Christine Chavez, Takaaki Tsuchida
Hydration with magnesium and mannitol without furosemide prevents the nephrotoxicity induced by cisplatin and pemetrexed in patients with advanced non-small cell lung cancer
Keiko Muraki, Ryo Koyama, Yuichiro Honma, Shigehiro Yagishita, Takehito Shukuya, Rina Ohashi, Fumiyuki Takahashi, Kenji Kido, Shin-ichiro Iwakami, Shinichi Sasaki, Akihiko Iwase, Kazuhisa Takahashi
Local control rates with five-fraction stereotactic body radiotherapy for oligometastatic cancer to the lung
Deepinder Singh, Yuhchyau Chen, Mary Z. Hare, Kenneth Y. Usuki, Hong Zhang, Thomas Lundquist, Neil Joyce, Michael C. Schell, Michael T. Milano
Theoretical models of carcinogenic particle deposition and clearance in children’s lungs
Robert Sturm
A novel paradigm in the treatment of oligometastatic non-small cell lung cancer
Salma K Jabbour, Parima Daroui, Dirk Moore, Edward Licitra, Molly Gabel, Joseph Aisner
Radiotherapy for a second primary lung cancer arising post-pneumonectomy: planning considerations and clinical outcomes
Sashendra Senthi, Cornelis J. A. Haasbeek, Frank J. Lagerwaard, Wilko F. Verbakel, Patricia F. de Haan, Ben J. Slotman, Suresh Senan
Impact of metformin use on survival in locally-advanced, inoperable non-small cell lung cancer treated with definitive chemoradiation
Inaya Ahmed, Adam Ferro, Alan Cohler, John Langenfeld, Sujani G. Surakanti, Joseph Aisner, Wei Zou, Bruce G. Haffty, Salma K. Jabbour
Utility of EBUS-TBNA for diagnosis of mediastinal tuberculous lymphadenitis: a multicentre Australian experience
James Geake, Gary Hammerschlag, Phan Nguyen, Peter Wallbridge, Grant A. Jenkin, Tony M. Korman, Barton Jennings, Douglas F. Johnson, Louis B. Irving, Michael Farmer, Daniel P. Steinfort
Comparative outcomes of squamous and non-squamous non-small cell lung cancer (NSCLC) patients in phase II studies of ASA404 (DMXAA) – retrospective analysis of pooled data
Mark J McKeage, Michael B Jameson, AS1404-201 Study Group Investigators
High prevalence of gene abnormalities in young patients with lung cancer
Osamu Nagashima, Rina Ohashi, Yasuko Yoshioka, Ai Inagaki, Manabu Tajima, Yoshika Koinuma, Shin-ichiro Iwakami, Akihiko Iwase, Shinichi Sasaki, Shigeru Tominaga, Kazuhisa Takahashi
Home-based exercise: promising rehabilitation for symptom relief, improved functional status and quality of life for post-surgical lung cancer patients
Amy J. Hoffman, Ruth Ann Brintnall, Alexander von Eye, Lee W. Jones, Gordon Alderink, Lawrence H. Patzelt, Jean K. Brown
Thoracic malignant solitary fibrous tumors: A population-based study of survival
Michael T Milano, Deepinder P Singh, Hong Zhang
Differences in chemosensitivity between primary and paired metastatic lung cancer tissues: In vitro analysis based on the collagen gel droplet embedded culture drug test (CD-DST)
Masahiko Higashiyama, Jiro Okami, Jun Maeda, Toshiteru Tokunaga, Ayako Fujiwara, Ken Kodama, Fumio Imamura, Hisayuki Kobayashi
High-resolution CT findings of patients with pulmonary nocardiosis
Naoki Tsujimoto, Takeshi Saraya, Ken Kikuchi, Saori Takata, Yasuyuki Kurihara, Sayuki Hiraoka, Hiroshi Makino, Shota Yonetani, Koji Araki, Haruyuki Ishii, Hajime Takizawa, Hajime Goto
Signal stratification of autoantibody levels in serum samples and its application to the early detection of lung cancer
Graham F. Healey, Stephen Lam, Peter Boyle, Geoffrey Hamilton-Fairley, Laura J. Peek, John F. R. Robertson

Review Article

Molecular biology of lung cancer
Wendy A. Cooper, David C. L. Lam, Sandra A. O’Toole, John D. Minna
Nontuberculous mycobacterial pulmonary infections
Margaret M. Johnson, John A. Odell
Treatment of advanced non small cell lung cancer
Maria Anna Bareschino, Clorinda Schettino, Antonio Rossi, Paolo Maione, Paola Claudia Sacco, Rosario Zeppa, Cesare Gridelli
Chemotherapy advances in small-cell lung cancer
Bryan A. Chan, Jermaine I. G. Coward
Electromagnetic navigation bronchoscopy: A descriptive analysis
Steven Leong, Hong Ju, Henry Marshall, Rayleen Bowman, Ian Yang, Ann-Maree Ree, Cathy Saxon, Kwun M Fong
Targeted therapy in lung cancer: IPASS and beyond, keeping abreast of the explosion of targeted therapies for lung cancer
Peter Savas, Brett Hughes, Benjamin Solomon
Stereotactic ablative radiotherapy for stage I NSCLC: Recent advances and controversies
Suresh Senan, David A. Palma, Frank J. Lagerwaard
The anticipation and management of air leaks and residual spaces post lung resection
Michael Rolf Mueller, Beatrice A. Marzluf
Exploiting sensitization windows of opportunity in hyper and hypo-fractionated radiation therapy
Anish Prasanna, Mansoor M. Ahmed, Mohammed Mohiuddin, C. Norman Coleman
Ultrasound techniques in the evaluation of the mediastinum, part 2: mediastinal lymph node anatomy and diagnostic reach of ultrasound techniques, clinical work up of neoplastic and inflammatory mediastinal lymphadenopathy using ultrasound techniques and how to learn mediastinal endosonography
Christian Jenssen, Jouke Tabe Annema, Paul Clementsen, Xin-Wu Cui, Mathias Maximilian Borst, Christoph Frank Dietrich
Revisiting signs, strengths and weaknesses of Standard Chest Radiography in patients of Acute Dyspnea in the Emergency Department
Luciano Cardinale, Giovanni Volpicelli, Alessandro Lamorte, Jessica Martino, Andrea veltri
The continuing role of chemotherapy for advanced non-small cell lung cancer in the targeted therapy era
Zarnie Lwin, Jonathan W. Riess, David Gandara
MicroRNAs in mesothelioma: from tumour suppressors and biomarkers to therapeutic targets
Glen Reid
Pleural controversies: image guided biopsy vs. thoracoscopy for undiagnosed pleural effusions?
Giles Dixon, Duneesha de Fonseka, Nick Maskell
Preservation solutions for cardiac and pulmonary donor grafts: a review of the current literature
Nicholas Latchana, Joshua R. Peck, Bryan Whitson, Sylvester M. Black
Active-specific immunotherapy for non-small cell lung cancer
Hauke Winter, Natasja K. van den Engel, Margareta Rusan, Nina Schupp, Christian H. Poehlein, Hong Ming Hu, Rudolf A. Hatz, Walter J. Urba, Karl Walter Jauch, Bernard A. Fox, Dominik Rüttinger
Advanced imaging in COPD: insights into pulmonary pathophysiology
Stephen Milne, Gregory G. King
Advances in lung adenocarcinoma classification: a summary of the new international multidisciplinary classification system (IASLC/ATS/ERS)
Elizabeth R. Tang, Andrew M. Schreiner, Bradley B. Pua
Diagnosis and early detection of COPD using spirometry
David P. Johns, Julia A.E. Walters, E. Haydn Walters
Improving radiotherapy planning, delivery accuracy, and normal tissue sparing using cutting edge technologies
Carri K. Glide-Hurst, Indrin J. Chetty
Pediatric lung transplantation: indications and outcomes
Stephen Kirkby, Don Hayes Jr
Staging lymph node metastases from lung cancer in the mediastinum
Mario D. Terán, Malcolm V. Brock
JTD special edition ‘Hot Topics in COPD’—The microbiome in COPD
Daniel C. Chambers, Shaan L. Gellatly, Philip Hugenholtz, Philip M. Hansbro
Lung donor selection criteria
John Chaney, Yoshikazu Suzuki, Edward Cantu III, Victor van Berkel
Molecular markers to predict clinical outcome and radiation induced toxicity in lung cancer
Joshua D. Palmer, Nicholas G. Zaorsky, Matthew Witek, Bo Lu
Lung cancer screening: identifying the high risk cohort
Michael W. Marcus, Olaide Y. Raji, John K. Field
Pleural controversies: indwelling pleural catheter vs. pleurodesis for malignant pleural effusions
Marc Fortin, Alain Tremblay
New techniques for assessing response after hypofractionated radiotherapy for lung cancer
Sarah A. Mattonen, Kitty Huang, Aaron D. Ward, Suresh Senan, David A. Palma
Supportive and palliative care for lung cancer patients
Patsy Yates, Penelope Schofield, Isabella Zhao, David Currow

Case Report

First report of a novel liquid nitrogen adjustable flow spray cryotherapy (SCT) device in the bronchoscopic treatment of disease of the central tracheo-bronchial airways
Robert Browning, Scott Parrish, Saiyad Sarkar, J. Francis Turner Jr
Severe amiodarone induced pulmonary toxicity
Nicholas Nacca, Castigliano M Bhamidipati, Luke S Yuhico, Sowmya Pinnamaneni, Tamas Szombathy


Guidelines for the diagnosis and treatment of malignant pleural mesothelioma
Nico van Zandwijk, Christopher Clarke, Douglas Henderson, A. William Musk, Kwun Fong, Anna Nowak, Robert Loeragan, Brian McCaughan, Michael Boyer, Malcolm Feigen, David Currow, Penelope Schofeild, Beth Ivimey Nick Pavlakis, Jocelyn McLean, Henry Marshall, Steven Leong, Victoria Keena, Andrew Penman

Research Highlight

Gene expression assays as prognostic and predictive markers in early stage non-small cell lung cancer
Tom Donnem, Roy M Bremnes, Lill-Tove Busund, Sigve Andersen, Francesco Pezzella

Short Communication

The sleep apnea cardiovascular endpoints (SAVE) trial: Rationale and start-up phase
R Doug McEvoy, Craig S Anderson, Nick A Antic, Baoyuan Chen, Quanying He, Emma Heeley, Shaoguang Huang, Yining Huang, Jiguang Wang, Nanshan Zhong

Circulating Tumor Cells

Detection methods of circulating tumor cells
Klaus Pantel, Catherine Alix-Panabières

Original Article

Suppressive oligonucleotides inhibit inflammation in a murine model of mechanical ventilator induced lung injury
Julia Scheiermann, Dennis M. Klinman
Five-year update on the mouse model of orthotopic lung transplantation: Scientific uses, tricks of the trade, and tips for success
Xue Lin, Wenjun Li, Jiaming Lai, Mikio Okazaki, Seiichiro Sugimoto, Sumiharu Yamamoto, Xingan Wang, Andrew E. Gelman, Daniel Kreisel, Alexander Sasha Krupnick
A pooled analysis of advanced nonsquamous non-small cell lung cancer patients with stable treated brain metastases in two phase II trials receiving bevacizumab and pemetrexed as second-line therapy
Matthew A. Gubens, Jody C. Chuang, Wallace Akerley, Corey J. Langer, Christelle Clément- Duchêne, Melanie San Pedro-Salcedo, A. Dimitrios Colevas, Konstantin Dragnev, Mark A. Socinski, Heather A. Wakelee
Pleurodesis: a comparison of two sclerosing agents for pleural effusions in Mozambique
Ivo Figueiredo, Anilsa Cossa, Anila Hassane, José Sousa, Joaquim Pondo, João Teixeira, Kevan Akrami, Susannah K. Graves, Atul Malhotra, Elizabete A. Nunes

Review Article

Atypical antibody responses to influenza
Dalton Hermans, Richard J. Webby, Sook-San Wong
What can individuals do to reduce personal health risks from air pollution?
Robert Laumbach, Qingyu Meng, Howard Kipen
The role of rotors in atrial fibrillation
David E. Krummen, Vijay Swarup, Sanjiv M. Narayan
Current outcomes of off-pump versus on-pump coronary artery bypass grafting: evidence from randomized controlled trials
Daniel Fudulu, Umberto Benedetto, Gustavo Guida Pecchinenda, Pierpaolo Chivasso, Vito Domenico Bruno, Filippo Rapetto, Alan Bryan, Gianni Davide Angelini
Staging lymph node metastases from lung cancer in the mediastinum
Mario D. Terán, Malcolm V. Brock
Improving radiotherapy planning, delivery accuracy, and normal tissue sparing using cutting edge technologies
Carri K. Glide-Hurst, Indrin J. Chetty
Esophageal cancer: staging system and guidelines for staging and treatment
Mark F. Berry
Implementing the new IASLC/ATS/ERS classification of lung adenocarcinomas: results from international and Chinese cohorts
Ming-Ching Lee, Kyuichi Kadota, Daniel Buitrago, David R. Jones, Prasad S. Adusumilli
Premature menopause in young breast cancer: effects on quality of life and treatment interventions
Shoshana M. Rosenberg, Ann H. Partridge
Strategies for the acquisition of transcriptional and epigenetic information in single cells
Guang Li, Elda Dzilic, Nick Flores, Alice Shieh, Sean M. Wu
The role of transforming growth factor (TGF)-β in the infarcted myocardium
Nikolaos G. Frangogiannis
Utility of cardiac magnetic resonance for evaluation of mitral regurgitation prior to mitral valve surgery
Neil K. Mehta, Jiwon Kim, Jonathan Y. Siden, Sara Rodriguez-Diego, Javid Alakbarli, Antonino Di Franco, Jonathan W. Weinsaft
Adjuvant, neoadjuvant, and definitive radiation therapy for malignant pleural mesothelioma
Gwendolyn Cramer, Charles B. Simone II, Theresa M. Busch, Keith A. Cengel


Conservatism strikes back: later is better than earlier dialysis for acute kidney injury
Dana Bielopolski, Kamyar Kalantar-Zadeh
Sleep and critical illness: bridging the two pillars at the ATS 2016
Stuti J. Jaiswal, Atul Malhotra, Robert L. Owens
Temperature and duration targets during post-arrest care: choosing the right prescription for the right patient
John C. Greenwood, Abhishek Bhardwaj, Benjamin S. Abella
Examining the paradox of high high-density lipoprotein and elevated cardiovascular risk
Kavisha Singh, Anand Rohatgi
Mortality after red blood cell transfusions from previously pregnant donors: complexities in the interpretation of large data
Susan Kuldanek, Christopher C. Silliman
Optogenetic tools for cell biological applications
Abhirup Mukherjee, Nicole A. Repina, David V. Schaffer, Ravi S. Kane
Editorial on “Transcription factor SPZ1 promotes TWIST-mediated epithelial—mesenchymal transition and oncogenesis in human liver cancer”
Dan J. Raz
Editorial on “Can CT-PET and endoscopic assessment post-neoadjuvant chemoradiotherapy predict residual disease in esophageal cancer”
Chia-Ju Liu, Wei Lu
The hemodynamic impact of acute nasal continuous positive airway pressure treatment in hypertrophic cardiomyopathy: is it safe?
Bo Xu, Reena Mehra
Tumor spread through air space (STAS) is an important predictor of clinical outcome in stage IA lung adenocarcinoma
Hui-Zi Chen, Erin M. Bertino, Kai He
Antiviral prophylaxis of cytomegalovirus reactivation in immune competent patients—the jury remains out
Sara A. Mansfield, Charles H. Cook
Allosterically targeting EGFR drug-resistance gatekeeper mutations
Nicholas Spellmon, Chunying Li, Zhe Yang
Imaging homeostatic sleep pressure and circadian rhythm in the human brain
Zhuo Fang, Hengyi Rao
Tumor mutational burden (TMB) as a biomarker of response to immunotherapy in small cell lung cancer
Yanis Boumber

Letter to the Editor

Response to “VATS vs. thoracotomy regarding postoperative chronic pain”
Emine Ozgur Bayman, Kalpaj R. Parekh, John Keech, Timothy J. Brennan
The role of a decision analysis in treatment of T2N0 esophageal cancer
Tara R. Semenkovich, Bryan F. Meyers, Benjamin D. Kozower, Varun Puri

Case Report

Intraoperative near-infrared imaging can identify subcentimeter colorectal cancer lung metastases during pulmonary metastasectomy
Andrew D. Newton, Jarrod D. Predina, Lydia G. Frenzel-Sulyok, Michael H. Shin, Yiqing Wang, Sunil Singhal
A novel strategy for cardiopulmonary support during lung transplantation
Ramiro Fernandez, Malcolm M. DeCamp, Ankit Bharat

Review Article on Left Ventricular Assist Devices

Left ventricular assist device driveline infections: recent advances and future goals
Anne-Marie Leuck

Short Communication of Interventional Pulmonology Corner

Endobronchial ultrasound—guidance for interstitial photodynamic therapy of locally advanced lung cancer—a new interventional concept
Kassem Harris, Emily Oakley, David Bellnier, Gal Shafirstein

Below are the latest Journal of Thoracic Disease articles published online ahead of print publication.