Macrophage-enriched HMOX1 is an ischemia-reperfusion-responsive marker in the heart

Myocardial ischemia-reperfusion (I/R) injury triggers rapid innate immune activation, yet cell-type-resolved, I/R-responsive markers that bridge macrophage biology and translational relevance remain insufficiently defined. This study aimed to identify cell-type-resolved I/R-responsive markers in the heart and to clarify the translational relevance of macrophage-enriched HMOX1 in myocardial ischemia-reperfusion injury.