‘σήψις’ yesterday, sepsis nowadays: what’s changing?

Is my patient septic or not?—that is the question. Sepsis (from the ancient Greek, σήψις) is an “antique” medical issue, a multi-faced life threatening disease characterized by organ dysfunction due to a dis-regulated host response to infection (1). Hyper-inflammation and immunoparalysis (2) along with tissue damage caused by pathogens play a key role into the onset and progression of the disease.