Cancer’s smart bombs: tumor-derived exosomes target lung epithelial cells triggering pre-metastatic niche formation

The formation of the pre-metastatic niche is a crucial step towards metastasis. In this project, Liu and colleagues demonstrate that lung primary tumor derived exosomes selectively target and activate lung alveolar epithelial type 2 cells inducing the secretion of chemokines responsible for causing lung neutrophil invasion and thus promoting the formation of the pre-metastatic niche (1).