Do we have enough evidence for adjuvant postoperative chemoradiation in esophageal cancer?

There is little doubt that locally advanced esophageal cancer needs multimodality treatments. Multidisciplinary therapy comprising of surgery, chemotherapy, and radiotherapy have been widely introduced in an attempt to eliminate micrometastasis, reduce recurrence and improve prognosis in esophageal cancer. However, the optimal combination has been the subject of long standing debate.