Evacetrapib and cardiovascular outcomes: reasons for lack of efficacy

Theodosios D. Filippatos, Moses S. Elisaf


Cholesteryl ester transfer protein (CETP) inhibitors are a drug class targeting the enzyme CETP (1). The first CETP inhibitor, torcetrapib, was discontinued because of increased cardiovascular events that were attributed to off-target adverse effects (increased aldosterone and blood pressure) (2).

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