Current status of development and application of
mini-invasive thoracic technique
Mini-invasive thoracic technique has been developing rapidly,
which is manifested by more and more conceptual acceptation
from the public, quicker improvement and update in surgical
instruments of endoscopic surgery, wider scope of application
and more and more scholars to master and perform mini-invasive
thoracic surgery.
The development in instruments of mini-invasive thoracic
surgery, as the precondition of development and progress in
mini-invasive thoracic surgery, is characterized by the features
below:
Instruments of mini-invasive thoracic surgery appear to be
safe and practical, and have successive improvement and
diversification in function.
The specific instruments of open surgeries have been
successively developed into dedicated instruments of
endoscopic surgery.
The application of endoscopic mechanical suture device
generates faster fragmentation and reconstruction of organ
tissues.
The specific delicate instruments of endoscopic surgery
have rapid development and application.
The simple instruments structurally similar to the
conventional instruments are designed according to the
mini-incision.
In recent years, surgical robot is one of the advances in instruments of mini-invasive thoracic surgery. Generally
speaking, surgical robots refer to machines that are able to
perform or assist in performing surgical operations. However,
they are still needed to be controlled by a doctor to perform a
surgery currently. At present, the major robotic system mainly
consists of Aesop system, Zeus system, DaVince system, and so
on. If video-assisted thoracoscope is considered having realized
the revolution in input end of surgical information, the presence
of surgical robots then realizes the revolution in output end.
The combination of surgical robotic technique and remote
video transmission technique makes telesurgeries possible. In
September 2001, laparoscopic cholecystectomy was successfully
performed on a 68-year-old patient in a operation room (OR),
Strasbourg Hospital, France using the Zeus robot by a surgeon
controlling its movements through watching telescreen in New
York, America, 7000 kilometers far away from France and across
the Atlantic. The further mini-invasive thoracic surgery advances,
the more significant interpenetration, interaction and integration
across the techniques.
More and more thoracic surgeries were performed using miniinvasive
thoracic technique based on the scope of application.
Diseases of pleura membrane and chest wall
Thoracoscope technique has been commonly employed in
diseased pleura membrane biopsy, pleural decortication and
pleurodesis, or clearance of effusion, empyema and hematocele,
ligation of fractured intercostal arteries or ruptured thoracic
ducts. In 1988, Nuss, an American doctor, performed Nuss
surgery to treat funnel chest by hanging up the sternum after
placing arcuate buttress plate on the back of sternum, which was
a major advance in treatment of funnel chest. These surgeries
are uncomplex in technique and low-risk. Thoracic surgery can
minimize trauma and greatly improve the accuracy of surgeries,
which is thus fit for application.
Lung diseases
According to surgical skills, the surgical procedures can be
allocated into lung biopsy, pulmonary resection, pulmonary
lobectomy, pneumonectomy and bronchoplasty surgery. At
present, all of surgeries above can be performed by using miniinvasive
thoracic technique in terms of the surgical technology.
Nevertheless, the role of mini-invasive thoracic technique
in treatment may be differential based on different diseases,
different disease degrees and surgeons with different levels of
proficiency.
Lung biopsy and pneumoresection are surgeries that only
need to remove a fraction of lung tissue from patients mainly
for a definite diagnosis and sometimes for direct treatments.
In the surgical diagnosis and treatments of lung diseases, these
surgeries need the least excisional tissue, the lowest difficulty level of mini-invasive thoracic technique hence the most
common use and most obvious advantages of mini-invasive
thoracic technique, among which the most commonly seen
are pulmonary nodule biopsy, diffuse lung disease biopsy and
treatment of pneumothorax pulmonary bullae. Traditionally,
the procedures above are performed using 2 or 3 incisions (1
observation incision + 1 or 2 operational incisions). Along with
advance of delicate instruments and surgical skills, surgeries
can be performed with only one incision by using one-channel
cannula, or much smaller needle-type thoracoscope which
further improves the mini-invasiveness of surgery.
For those surgeries requiring removal of a relatively larger
part of lung tissue, they are usually performed after confirming
diagnosis. These surgeries are usually performed when
pulmonary lobectomy can’t be tolerated by tumor patients,
including wedge resection, segmentectomy, and lung volume
reduction surgery for severe emphysema and bullectomy. In
addition, these surgeries are uncomplex and convenient mainly
involving successive excision of lung tissue and suture by using
the endoscopic suture cutting instrument, without individual
treatment of pulmonary vessels and bronchia involved. Such
mini-invasive surgeries also have significant advantages, and are
commonly used.
Based on diseases requiring anatomic lobectomy of lung
such as lung cancer, bronchiectasis and destroyed lung,
anatomic treatments of blood vessel and bronchia are involved
in these surgeries. Reliableness and safety are highlighted
in order to avoid massive hemorrhage during surgery and
bronchopleural fistula after surgery. Notably, lung cancer needs
to be guaranteed a reliable efficacy of lymph node dissection.
Microtrauma of thoracoscopic surgery enables some patients
whose pulmonary function can’t tolerate conventional surgeries
originally to undergo surgical treatments. In 1992, VATS
pulmonary lobectomy was first reported by Lewis (
3). So far
the most commonly employed surgical approaches have two
aspects: a) unopen incision. VATS is performed entirely under
thoracoscope; b) open incision. Hybrid VATS is performed
by combination of thoracoscope-assisted observation and
macroscopic vision. There is technically no problem in
pulmonary lobectomy performed using the first approach,
with 1 observational incision + 1 longer surgical incision + 1or
2 incisions for assistance of stretch. For the second approach,
surgeries need to be performed entirely on two-dimensional
plane under thoracoscope by using relatively longer endoscopic
surgical instruments, which greatly requires an intense surgical
perception from a surgeon. The surgical time needed of this
approach is much longer than that of the first approach,
whereas the pain may be favorably alleviated after surgery. 1
observational incision + 1 longer open incision are usually
needed in the second approach. Such surgeries can be performed
on the operational field in combination of two-dimension
and three-dimension under partial direct vision. Moreover,
conventional instruments can be employed. The advantages of
this approach are improved precision and speed, decreased time
of manual suture and enlarged surgery space. This approach
is more practical in surgeries involving reconstruction such as
bronchoplasty. Nevertheless, there may be a more significant
pain after surgery because of the opened incision and the
accessorial incision over 2cm. Therefore, each approach has its
own advantages and disadvantages, which should be selected
depending on the performing level of surgeons, balance across
safety, efficiency and economic expenditure, with no absolute
rules.
Along with the increase of surgical practice, people have
found various advantages of VATS pneumonectomy and
dismissed many worries. The multicenter study (Cancer and
Leukemia Group B 39802) supported by Swanson showed a
lower incidence rate of postoperative complications and shorter
retention time of thoracic ducts of VATS pneumonectomy as
compared with those of the conventional thoracic surgery (
4).
Furthermore, a summary report of 1100 cases by McKenna
demonstrated a very low mortality rate (5). In addition, more studies have shed light on
other advantages of VATS pneumonectomy such as alleviated
pain after surgery, minimal blood loss during surgery, more
favorable pulmonary function after surgery (
6).
There were still some conflicts over VATS technique for
treatment of lung cancer before 2006. These problems mainly
center on as to whether the longer surgical time and frequent
stretch of pulmonary lobe will lead to iatrogenic metastasis,
whether VATS technique contributes to a safe pulmonary
lobectomy and an effective lymph node dissection under
circumstance of nondirect vision. If it’s possible, whether
the surgical time and learning time of VATS technique will
be increased, and whether this will decrease the charm of
microtrauma in this surgery. Actually, thoracoscope is an
instrument used for diagnosis by surgeons, but not a diagnostic
purpose. However by the year 2006, along with the application of
VATS technique for 14 years, statistics of large numbers of cases
and reports of event free survival had been done. Thus VATS
radical resection of pulmonary carcinoma was identified and
believed to be included in the standard treatment approach of
resection of pulmonary carcinoma by National Comprehensive
Cancer Network (NCCN) guideline, which is also greatly
suggested for old people and people with poorer constitution.
VATS system can provide better lighting and clear magnified
images of the deep part and the details, which is impossible for
the conventional surgeries. As long as surgeons have a good
foundation of general thoracic technique and proficient skills
in mastering thoracoscope, and the VATS technique and the
conventional thoracotomy is organically combined, sufficient
scope of excision and standard lymph node dissection can be
accomplished during tumor surgery. If conventional surgeries can be performed with assistance of thoracoscope, this can also
improve the surgeons’ grasp of the overall surgical situation. In
the contrary, adhering too strictly to the incision 1cm longer or
shorter than the standard will lead to the ossification of surgeries
because the patient’s condition + equipment condition + the
surgeon’s skill = personalized mini-invasive thoracic technique.
For an individual person in realistic society, a patient needs
the most suitable surgical approach but not really the highest
technical approach. However, the thoracoscope just resolves the
surgical access without changing the essence of thoracic surgery.
The efficacy is the premise, and the safety is the first. If VATS or
VAMT is found not to satisfy the safe radical excision and not
to achieve the efficacy of conventional surgeries, such surgery
should be immediately transferred into micro-incision surgery,
which also should be a major principle of mini-invasive thoracic
surgery. In recent years, along with the development of miniinvasive
thoracic technique and an update of conception, miniinvasive
thoracic surgery can be performed not only on patients
with stage I or stage II lung cancer, but patients with stage III
lung cancer by quite a few scholars.
Of mini-invasive techniques, video mediastinoscopy also
deserves to be mentioned. Video mediastinoscopy is performed
by inserting the mediastinoscope through the small incisions
beside the neck and the sternum to visually diagnose and remove
the pathological tissues or swelled lymph nodes in peri-trachea,
carinal trachea and bronchial region with combination of video
technique. Although mediastinoscopic technology has been
promoted in the clinical application for more than 40 years,
video mediastinoscopy was first clinically used by Sortini et al
in 1994 (
7). In addition to mediastinal lymph node biopsy, the
traditional mission, video mediastinoscope may allow for lymph
node dissection, excision of mediastinal mass, or excision of
esophageal carcinoma instead of thoracoscope and treatments of
malignant pleural effusion (MPE) and palmar hyperhidrosis, etc.
Esophageal diseases
Video-assisted thorascope is currently combined with
laparoscope, which almost involves every surgical treatment
of esophageal diseases. For treatments of benign esophageal
diseases, Heller myotomy on thoracoscope has been considered
as a safe and effective approach in treatment of esophageal
achalasia, and VATS resection of benign esophageal neoplasm
or esophageal diverticulum is also convenient and simple,
which is thus commonly performed. Nevertheless, there are still
debates over mini-invasive technique in treatment of malignant
esophageal diseases. In 1991, thoracoscopic lobectomy of
esophageal cancer was first performed by Collard and Gossot.
At present, along with the development of more than ten
years, NCCN believes that mini-invasive esophagectomy can
favorably decrease the occurrences of complications and the
recovery time after surgery as compared with the conventional
surgery, and mini-invasive surgery is suitable for the old patients
with esophageal cancer. But so far no clinical randomized trial
can be found to verify a better improved long term survial
rate of minimally invasive lobectomy of esophageal cancer as
compared with that of the conventional surgery, in many cases,
the conventional open lobectomy of esophageal cancer is still
considered as the standard method. At present, video-assisted
thoracoscope or the assisted incision is more frequently used
in gastroesophagostomy by mobilizing from the esophagus to
the median abdominal incision, or laparoscope by mobilizing
stomach, chest or internal collar incision. In the past few years,
the combination of thoracoscope and laparoscope has been more
and more commonly used in both esophageal cancer treatment
and reconstruction.
Mediastinal diseases
Most of mediastinal tumors and surgical diseases can be treated
with mini-invasive surgery such as mediastinal ectopic thyroid
gland, thymic cyst, myasthenia gravis and stage I thymoma,
which thus is popular with more and more patients and doctors.
Mini-invasive mediastinoscopy combined with thoracoscope has
a significant improvement in the surgical visual field. Compared
with the conventional surgery, mini-invasive mediastinoscopy
has a greatest advantage of slight blood loss, followed by
decreased hospitalized time, good cosmetic effect, rapid recovery
and less pain. Nevertheless, the mini-invasive mediastinoscopy
has raised some doubts for using mini-invasive thymusectomy
in treatment of myasthenia gravis (MG) and stage I thymoma
as to whether the nidus tissues can be entirely removed by miniinvasive
surgery, especially thoracoscopic surgery. But as the
days goes by, mini-invasive mediastinoscopy is increasingly
performed on patients hence less and less doubts over this point.
For operation on thymus, total thymectomy can be performed
by using one of the mini-invasive surgical approaches including
an unilateral or bilateral thoracoscope, a neck incision, and
the combination of these two approaches, if the patients are
seriously selected and the surgery is carefully performed, which
is no less effective than the conventional open thoracotomy.
However, operation on thymus should be immediately converted
to midsternal incision surgery or anterio-lateral incision surgery,
when thymoma is found to have malignant syndromes such as
invasion of adjacent tissues, or the thymus can’t be removed
entirely using the thoracoscope during surgery.
Heart diseases
At present, most of surgeries in the field of cardiac surgery can
be performed using video-assisted thoracic technique. The
application of thoracoscope technique in cardiac surgery has
several major aspects below:
Thoracoscope-assisted cardiac surgery: Thoracoscopeassis ted cardiac surgery refers to a technique that involves
insertion of a thoracoscope used as the light source or
an image collector of the specific regions through a small
incision of chest wall under direct vision. In 1995 and
1996, the success of thoracoscope-assisted mini-invasive
direct coronary artery bypass was reported by Benetti
and Stevens, respectively. In 1996, Chang was the first to
perform 8 repairs of auricular septal defect by making a 4-
to 7-cm incision under video-assisted thoracoscope, which
achieved a satisfactory result. In addition, repair of mitral
valve was successfully performed using thoracoscope by
Carpentier the same year. In 1997, replacement of mitral
valve was performed using a thoracoscope by Chitwood.
In 1998, replacement of tricuspid valve was successfully
performed using thoracoscope by Robin. At present,
thoracoscope-assisted cardiac surgery, with a most mature
development, has a significant decrease in surgical trauma
as compared with the conventional surgery, whereas there
remains a relatively large incision.
Robotic thoracic surgery: In 2002, Torracca et al reported
that 7 repairs of auricular septal defect was successfully
performed with the da Vinci Surgical System by using
peripheral extracorporeal circulation, blocking of aorta
and cardiac cold penetration techniques under the
thoracoscope, and all the patients recovered well after
surgery. Nevertheless, there exist two great defects on
robotic thoracic surgery. The first is the lack of visual and
tactile feedbacks from surgeons, followed by the great
defects in surgical equipments including inharmony
operation, relatively higher technical difficulty and longer
surgical time. Moreover, these equipments are very
expensive and thus remain in the stage of exploration.
Video-assisted thoracic surger y: Compared with
thoracoscope-assisted cardiac surgery, video-assisted
thoracic surgery is performed by insertion of the specific
instrument through a tiny incision in chest wall under
observation of video-assisted thoracoscopic image
capture screen. Video-assisted thoracic surgery is in
best conformity with the principle, whereas it requires
a relatively higher technique, which thus prohibits the
widespread use of video-assisted thoracic surgery. In 1994,
ligation of patent arterial duct was first performed using
VATS in mainland China, which achieved a favorable
efficacy. From 2000 to 2001, atrial septal defects (ASD),
ventricular septal defect, replacement of mitral valve,
Ebstein orthopedic surgery and coronary artery bypass
surgery were successively performed under video-assisted
thoracoscope. For skilled operators, the operation time of
video-assisted thoracic surgery can be as low as 1/3~1/4 of
that of robotic thoracic surgery, which can save a majority
of financial and material resources and thus tallies with the
realistic situation of China.
Thoracic surgery under thoracoscope can be classified into 2
levels depending on the degree of trauma: 1) Thoracoscopeassisted
surgery: The surgical approach involves technical
applications of thoracoscope technolog y, peripheral
extracorporeal circulation and myocardial preservation in
congenital cardiac surgery. The incisions located beside the
sternum and in the lower right breast, can be further reduced
to 4- to 8-cm, which then further decreases the degree of
trauma. However, the surgical procedures inside the chest
cavity still needs to be performed under direct vision using this
approach which hasn’t reached the level of pure thoracoscope.
2) Pure thoracic surgery. This surgery aims at being performed
by inserting a thoracoscope through a hole instead of a tiny
incision without involving direct vision. In the present historical
conditions, the operators can fully exert the effects of surgical
techniques including the modern thoracic technique, peripheral
extracorporeal circulation and myocardial preservation according
to practical situation, and minimize the surgical trauma.