Neoadjuvant strategy for stage IIIA-N2 non-small cell lung cancer: chemoradiation or chemotherapy alone?

This pooled study of two phase II trials (RTOG 0229 and 0839) aimed to assess safety and feasibility of anatomic resection following induction therapy with platinum-based chemotherapy and full-dose thoracic radiation for resectable N2 positive stage IIIA non-small cell lung cancer (NSCLC). And it concluded that lobectomy could be performed safely after full-dose concurrent chemoradiation. We would like to discuss this topic further from surgical point of view in the real world.