Should cT2N0M0 be managed as a localized or locally advanced esophageal carcinoma?

Esophageal carcinoma (EC) comprises two well-defined histotypes, such as squamous cell carcinoma (SCC) and adenocarcinoma (AC), which are different each other in terms of etiology, epidemiology, prognosis and response to therapy (1). Unfortunately most studies about EC and even gastric cancer (GC) included indifferently SCC and AC, therefore making difficult to correlate the outcome to the specific histotype (2-6).