While size matters—advanced “Radiomics” remain promising for the clinical management of ground glass opacities

The increasing utilization of diagnostic high-resolution chest CT (HRCT) scans in clinical practice and the implementation of low-dose HRCT lung cancer screening are resulting in the identification of a growing number of incidentally and screen-detected pure ground-glass nodules (pGGN) (1-3). Consequently, the notoriously difficult clinical management of persistent (defined present for ≥3 months) sub-solid pulmonary nodules including pGGN, represents an increasingly recognized conundrum.