Current perspectives for the size measurement of screeningdetected lung nodules

Lung cancer is the leading cause of cancer-related mortality worldwide. National Lung Screening Trial (NLST) demonstrated reduced lung cancer mortality of 20% for whom underwent annual low-dose CT screening (1). For the screening-detected nodules, size measurement is mandatory as the nodule size is directly proportional to the lung cancer risk (2). For the size estimation, unidimensional or bi-dimensional diameter measurement have been the standard in practice.