Hydrocortisone plus fludrocortisone: Taichi of risk hedge for improving adults with septic shock

We read with interest the work presented by Annane et al. (1) in which the authors reported that hydrocortisone plus fludrocortisone therapy significantly improved 90-day all-cause mortality in patients with septic shock compared with placebo. Interestingly, recent work presented by Venkatesh et al. (2) did not favor hydrocortisone therapy alone in patients with septic shock undergoing mechanical ventilation.