Sepsis: early interventions count but not RRT!

Acute kidney injury (AKI) frequently affects critically ill patients (1). While there are many measures to theoretically prevent the development of AKI or, at least, avoid worsening of AKI (2,3), ultimately, renal replacement therapy (RRT) is often required in the disease management of these patients. However, a continually vexing problem, which often arises when planning the initiation of RRT in critically ill patients, is finding the ideal time to instigate extracorporeal treatment.