Original Article

A retrospective study of low-dose apatinib combined with S-1 in patients with advanced non-small cell lung cancer

Tong Zhou, Changling Wu, Changsong Zhang, Peng Li, Huajie Dong, Xiaoyue Zhou, Hongjun Lu, Chuang Qi, Yang Ling


Background: The current regimens for advanced non-small cell lung cancer (NSCLC) patients are deficient due to failings in standard treatments. This retrospective study aimed to assess the efficacy and safety of low-dose apatinib in combination with S-1 therapy in a NSCLC setting.
Methods: In this retrospective study, advanced NSCLC patients who failed standard treatment in Changzhou Cancer Hospital of Soochow University were screened for eligibility. Progression-free survival (PFS) was set as the primary endpoint. Overall response rate (ORR), disease control rate (DCR), overall survival (OS), and the safety profile were considered to be the secondary endpoints.
Results: A total of 31 eligible patients were included. The median PFS (mPFS) was 102 days (95% CI: 57–147 days). ORR was achieved in 7 patients (22.6%; 95% CI: 11.1–38.2%) and DCR was maintained in 23 patients (74.2%; 95% CI: 58.2–86.5%). The median OS (mOS) was 422 days (95% CI: 148–696 days). Patients with a history of smoking tended to have a shorter OS without significant differences (HR =4.105, 95% CI: 0.874–19.288, P=0.074). Treatment-related grade III toxicity was observed in 5 patients (16%) and common grade I or II adverse events (AEs) were fatigue (42%), hypertension (32%), and hand-foot-skin reaction (23%).
Conclusions: Combination of low-dose apatinib and S-1 could be an effective and tolerable choice for advanced NSCLC patients who are unable to benefit from standard treatment; however, further exploration in larger clinical trials is needed.

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