Late clinical outcomes of aortic valve replacement with Carpentier-Edwards pericardial valves
Original Article

Late clinical outcomes of aortic valve replacement with Carpentier-Edwards pericardial valves

Hyoung Woo Chang1#, Wook Sung Kim2#, Joong Hyun Ahn3, Keumhee C. Carriere3,4, Dong Seop Jeong2, Yang Hyun Cho2, Kiick Sung2, Pyo Won Park2

1Department of Thoracic and Cardiovascular Surgery, Seoul National University Bundang Hospital, Gyeonggi-do, Republic of Korea;2Department of Thoracic and Cardiovascular Surgery, 3Bioinformatics Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;4Department of Mathematical and Statistical Sciences, University of Alberta, Edmonton, AB, Canada

Contributions: (I) Conception and design: PW Park, HW Chang; (II) Administrative support: PW Park, WS Kim; (III) Provision of study materials or patients: PW Park, HW Chang, WS Kim; (IV) Collection and assembly of data: PW Park, HW Chang; (V) Data Analysis and interpretation: HW Chang, PW Park, WS Kim; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

#These authors contributed equally to this work.

Correspondence to: Pyo Won Park, MD, PhD. Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Republic of Korea. Email:

Background: The present study aimed to compare the long-term clinical and hemodynamic outcomes of aortic valve replacement using Carpentier-Edwards Perimount (Perimount) or Perimount Magna (Magna) valves.

Methods: We enrolled 430 patients who underwent aortic valve replacements with Perimount (n=58) or Magna (n=372) valves [1998–2013]. Multivariable and inverse probability of treatment weight (IPTW) analyses were performed.

Results: Before IPTW analysis, the overall 8-year survival rate differed significantly between the groups [Perimount 90%±4% vs. Magna 76%±4%; P=0.02; hazard ratio (HR): 0.37 for the Perimount group; 95% confidence interval (CI): 0.17–0.83]. Multivariable analysis of the overall survival identified Perimount valve use as a protective factor (P=0.009; HR: 0.32; 95% CI: 0.14–0.75). Independent risk factors of overall survival were older age, male sex, higher preoperative left ventricular mass index, lower ejection fraction, lower aortic valve pressure gradient, and lower haemoglobin. After applying IPTW, overall survival was again found to be significantly longer in the Perimount group (P=0.04; HR: 0.43; 95% CI: 0.20–0.93). Event-free survival was also better in the Perimount group (P=0.006; HR: 0.38; 95% CI: 0.19–0.75). However, the Magna group had significantly lower aortic valve pressure gradients at one year and five years postoperative.

Conclusions: Although Magna use led to decreased aortic valve pressure gradients at follow-up, overall and event-free survival rates were significantly better with use of the Perimount valve. Additional and larger studies are needed to confirm these results.

Keywords: Prosthesis; aortic stenosis (AS); aortic valve replacement; hemodynamics; survival

Submitted Sep 11, 2019. Accepted for publication Oct 31, 2019.

doi: 10.21037/jtd.2019.11.65


Since its introduction in 1982, the Perimount (Perimount) pericardial aortic valve has been used widely in patients. However, the hemodynamic disadvantages of this valve are a concern, especially in patients with a small aortic annulus. The Perimount Magna (Magna) valve, introduced in 2003, reportedly overcame the hemodynamic disadvantages of the Perimount valve. The Magna valve was designed for placement in the supra-annular position and provided a larger effective orifice area (EOA) than a size-matched Perimount valve (1). This is thought to lower the transvalvular pressure gradient, a significant surgical parameter, after aortic valve replacement (AVR). However, few studies have compared the clinical use of the Perimount and Magna valve in terms of postoperative outcomes. Given this, the proposed hemodynamic superiority of the Magna valve to the Perimount valve remains untested and unproven. Few papers have compared hemodynamic parameters in the early postoperative period. Here, we compared the postoperative clinical outcomes of Perimount and Magna valve recipients with severe aortic stenosis (AS) to evaluate the hemodynamic benefits of each valve type and their effects on long-term patient survival.


Study design

This is a retrospective observational study. Data were collected through a review of electronic medical records. The hospital institutional review board of Samsung Medical Center approved this study and waived any need for informed consent due to its retrospective nature (no. 2018-01-013). An analysis flow diagram is shown in Figure 1. A total of 441 AVR procedures were performed for the treatment of severe AS using the Perimount or Magna valves between 1998 and 2013 at Samsung Medical Center. Cases with concurrent mitral or tricuspid annuloplasty were included; those in which any other valves were replaced in the same operation were excluded. Concomitant coronary artery bypass grafting, ascending aorta procedure, Maze procedure, and aortic root widening procedure cases were included.

Figure 1 Study design and data analysis flow diagram. AVPG, aortic valve pressure gradient; AVR, aortic valve replacement; BSA, body surface area; CABG, coronary artery bypass grafting; CVA, cerebrovascular accident; eGFR, estimated glomerular filtration rate; IPTW, inverse probability of treatment weight; LVEF, left ventricular ejection fraction; LVMI, left ventricular mass index; MAP, mitral annuloplasty; MR, mitral regurgitation; NYHA Fc, New York Heart Association functional class; TAP, tricuspid annuloplasty; TR, tricuspid regurgitation.

Surgical techniques

All operations were performed with a full median sternotomy approach. Aortic cannulae were placed at the lesser curvature of the aortic arch and a standard bicaval cannulation was performed. Cold antegrade and/or retrograde blood cardioplegia was used for myocardial protection. In the Perimount group, transannular everting sutures were used in most cases (Figure 2A,B). In contrast, only the supra-annular non-everting suture technique was used in the Magna group (Figure 2C,D,E). For patients with an extremely small aortic annulus, an aortic root widening procedure was performed. Ascending aorta wrapping or replacement was performed when the ascending aorta diameter exceeded 45 mm. Patient-prosthesis mismatch (PPM) was defined as an EOA index ≤0.85 cm2/m2. The EOA index was calculated based on manufacturer-provided EOA values.

Figure 2 Surgical techniques of aortic valve implantation. (A,B) Depict intra-annular positioning of Perimount valve using an everting suture; (C,D,E) depict supra-annular positioning of Magna valve using a non-everting suture; (E) depicts the distorted aortic root and the relationship between the sewing ring and coronary orifices.

Perioperative management and follow-up

Transthoracic echocardiography was performed before discharge in all patients. In an outpatient clinic, patients were advised to undergo echocardiography at least once within the first postoperative year and then whenever possible during years two-three, three-five, and then after five years. All patients were prescribed warfarin for three months postoperatively. The target prothrombin time international normalized ratio was 1.5–2.0. Morbidity and mortality were defined per the “Guidelines for reporting mortality and morbidity after cardiac valve interventions” (2). “Events” in event-free survival included reoperation due to structural valvular deterioration, non-structural valvular dysfunction, major bleeding requiring the transfusion of ≥2 units of packed red blood cells, valve-related thromboembolism (including stroke), and prosthetic valve endocarditis.

Statistical analyses

A summary diagram of the analytic process used is presented in Figure 1. SAS 9.3 (SAS Institute, NC, USA) and PASW 20 (IBM SPSS Inc., Armonk, NY, USA) were used for all analyses. Student’s t and chi-square tests were used to compare continuous and categorical variables, respectively. Student’s t-test could suffice because there were only two study groups. Fisher’s exact tests were used when the categorical data were sparse. With unweighted original data, Kaplan-Meier survival curves were drawn and a Cox regression was used. Multivariable Cox analyses of overall mortality were performed to adjust the hazard ratio of Perimount use over Magna for various confounding variables. Variables that had an incidence of at least 5 were included in the multivariable analyses with the stepwise forward and backward selection method (entry probability of 0.20, removal probability of 0.05), while the factor “Use of the Perimount valve” was included in the multivariable analysis, regardless of variable selection process. These clinical and demographic variables included sex, age, hypertension, serum haemoglobin level, total bilirubin, New York Heart Association functional class III or IV, EuroScore, atrial fibrillation, preoperative mean aortic valve pressure gradient, preoperative left ventricular (LV) ejection fraction, preoperative LV mass index, concomitant ascending aorta wrapping or replacement, tricuspid annuloplasty, coronary artery bypass, and the Maze procedure. The proportional hazard assumption of the Cox model was verified using Schoenfeld residuals.

Alternatively, to balance the patients for differences in baseline characteristics between the Perimount and Magna groups, an inverse probability of treatment weight (IPTW) procedure was applied. IPTW method was chosen because it could minimize the dropouts. A logistic regression model was constructed to calculate the propensity score for each case in the Perimount and Magna groups (Table 1). After applying the IPTW procedure, acceptable standardized mean differences (<0.25) were observed for all characteristics except LV mass index (Figure 3). A clustered Cox regression analysis of overall survival and event-free survival based on the IPTW procedure was performed to evaluate and reconfirm the effect of valve choice. Preoperative LV mass was included as a covariate (because it was not well balanced between the groups after applying the IPTW, as per doubly robust procedure). The difference in changes in aortic valve mean pressure gradient (AVPG) over time was assessed using a generalized estimating equation method with a Bonferroni correction for multiple comparisons.

Table 1
Table 1 Patient characteristics before and after inverse probability of treatment weighting (IPTW)
Full table
Figure 3 Patient characteristics by group. Absolute mean differences before (hollow circles) and after (red-filled triangles) inverse probability of treatment weighting. AVPG, aortic valve mean pressure gradient; CABG, coronary artery bypass grafting; CVA, cerebrovascular accident; eGFR, estimated glomerular filtration rate; LV, left ventricular; MAP, mitral annuloplasty; MR, mitral regurgitation; NYHA, New York Heart Association; Preop., preoperative; TAP, tricuspid annuloplasty; TR, tricuspid regurgitation.


Patient characteristics and surgical data

Baseline patient characteristics are presented in Table 1. The mean age of the 430 patients included was 72±6 years. Of these patients, 243 (57%) were male. Concomitant ascending aorta replacement was performed in 43 patients (10%). The mean preoperative aortic valve pressure gradient was 60±19 mmHg and the LV mass index was 146±41 g/m2. Patients in the Magna group were significantly older and more frequently had diabetes and hypertension. However, there were significantly more patients with a New York Heart Association functional class rating of III or IV in the Perimount group. LV mass index was also significantly higher in the Perimount group. PPM (EOA index ≤0.85 cm2/m2) calculated based on the manufacturer-provided reference EOA was significantly more common in the Perimount group. The distribution of concomitant operations did not differ significantly between the groups. There were three 30-day mortality in Magna group, but none in Perimount group (P>0.999). The median follow-up period was 132 [interquartile range (IQR), 122–153] months in the Perimount group and 41 (IQR, 22–69) months in the Magna group (P<0.001). The completeness of follow-up was 97.5% for overall mortality because survival data from national medical insurance databases was used for all patients. However, the rate of loss to outpatient clinic during follow-up was 16%.

Multivariable analyses of overall survival

The results of univariable and multivariable analyses for overall mortality are shown in Table 2. Independent risk factors of overall survival were older age, male sex, higher preoperative left ventricular mass index, lower ejection fraction, lower aortic valve pressure gradient, and lower haemoglobin. Perimount valve use was a protective factor compared to Magna valve use [P=0.009; hazard ratio (HR): 0.32; 95% confidence interval (CI): 0.14–0.75], adjusted by all the significant risk factors above.

Table 2
Table 2 Multivariable Cox regression analysis of overall survival using original raw data (unweighted). A stepwise variable selection approach was used
Full table

IPTW applied analyses

The propensity score adjusted balance of standardized mean differences via IPTW is shown in Table 1 and Figure 3. Before applying the IPTW procedure, the incidence of PPM was significantly higher in the Perimount group [36/58 (62%) in the Perimount group vs. 23/372 (6%) in the Magna group; P<0.001]. Higher incidence of PPM in the Perimount group persisted after applying ITPW [30/53 (57%) in the Perimount group versus 22/370 (6%) in the Magna group; P<0.001]. Valve-related adverse outcomes adjusted by IPTW were not different between the two valve groups (Table 3).

Table 3
Table 3 Valve-related complications in all patients, before and after inverse probability of treatment weighting (IPTW)
Full table

Before applying the IPTW procedure (Figure 4), the eight-year overall survival was 90%±4% and 76%±4% in the Perimount and Magna groups, respectively (Perimount group: HR, 0.37; 95% CI: 0.17–0.83; P=0.016). Event-free survival in the Perimount group was significantly better than in the Magna group (86%±5% vs. 66%±5%, respectively; P=0.004; Perimount group: HR, 0.36; 95% CI: 0.18–0.72). Survival analyses adjusted via IPTW are shown in Figure 4B,D. The Perimount group’s superior overall and event-free survival rates persisted after applying the IPTW procedure. Clustered Cox regressions revealed that the Perimount group had better overall survival (HR, 0.43; 95% CI: 0.20–0.93; P=0.031). Event-free survival also indicated that Perimount valve use was associated with decreased risk (HR, 0.38; 95% CI, 0.19–0.75; P=0.006). We also compared long-term cardiac related mortality, and the survival curves are presented in the supplementary material. There was no significant difference in cardiac related mortality before and after IPTW (Figure S1). However, cause of death during long-term follow-up was not sufficiently reliable.

Figure 4 Survival analyses (Kaplan-Meier curves and multivariable Cox regression) before and after inverse probability of treatment weighting (IPTW). (A) Overall survival (before IPTW); (B) overall survival (after IPTW); (C) event-free survival (before IPTW); and (D) event-free survival (after IPTW). CI, confidence interval; HR, hazard ratio; No., number.
Figure S1 Cardiac related mortality. (A) Before inverse probability of treatment weighting (IPTW); (B) after IPTW. CI, confidence interval; HR, hazard ratio.

Figure 5 shows changes in AVPGs over time. The Perimount group generally had higher AVPGs, significant except at two-three and three-five years postoperative, per echocardiography.

Figure 5 Serial follow-up of mean aortic valve pressure gradient (mmHg), before inverse probability of treatment weighting (IPTW). P values were derived from generalized estimating equations with Bonferroni correction, after IPTW. Numbers of patients are shown in parentheses.


For the present study, we hypothesized that there would be a difference in long-term clinical outcomes between AVR cases in which Perimount or Magna valves were used. Multivariable analyses and IPTW-transformed analyses were performed to overcome differences in baseline patient characteristics between the groups. As a result, the Perimount group had significantly better outcomes than the Magna group in terms of overall and event-free survival. In contrast, AVPG was lower in the Magna group, and significant except at two-three and three-five years postoperative.

The Perimount valve has excellent durability, as reported by multiple studies (3,4). However, the Magna valve may offer additional benefits. For example, the Magna valve’s manufacturer has argued that it features improved hemodynamic performance and allows for supra-annular positioning (5,6). While conventional Perimount valves are designed for both intra- and supra-annular implantation, they are more frequently implanted in the intra-annular position. Intra-annular positioning is achieved by everting sutures on the aortic annulus. In valves with a supra-annular design, the sewing ring is placed on the annulus with a non-everting suture (Figure 2C). This supra-annular design allows for improved haemodynamics and dynamic oversizing. In particular, one study described the hemodynamic superiority of the Magna valve in terms of its AVPG (1). Several previous reports have also concluded that the supra-annular valve has a larger measured EOA (7-9). Regardless, it is unclear whether AVPG and EOA, as measured via echocardiography, represent hemodynamic superiority (10). In particular, it has not been demonstrated whether a low AVPG or high EOA leads to improved overall survival or decreased rates of cardiac-related events (11-15).

As with the factors mentioned above, evaluating LV outflow and aortic root haemodynamics is difficult due to several confounders. For instance, changes in the shape of the sinus of Valsalva after valve implantation. The relationship between the coronary orifice and the implanted valve’s sewing ring is also difficult to measure precisely and each patient exhibits unique anatomy. Therefore, validating the performance of a novel valve prosthesis requires long-term clinical outcomes (e.g., overall survival).

Although our results are somewhat unclear, it is possible that the Magna valve’s supra-annular design potentially worsens patients’ long-term results. In addition to the original height of the coronary artery orifice, the distance between the coronary artery orifice and the valve sewing ring also varies between patients. The sewing ring can be positioned closer to the coronary artery orifice in the supra-annular position rather than in the intra-annular position. Additionally, oversizing can distort the sinus of Valsalva, further reducing the distance between the coronary artery orifice and the sewing ring (Figure 2E) (12,16). This problem that can be caused by supra-annular positioning becomes even more serious with a smaller sinus of Valsalva (17). A recent study showed that a smaller left coronary ostia height (<12 mm) is more frequently encountered in Asian populations than among Caucasians (17). Finally, left main trunk obstruction after AVR in the supra-annular position using the Magna valve has been reported previously (18). Unfortunately, due to some data being missing, we were unable to analyse the size of the sinus of Valsalva in the patients assessed in the present study.

Despite the limitations discussed above, the hemodynamic superiority of the Magna valve, as measured via AVPG, was revealed by our results. We found that Magna valve use was associated with a significantly lower AVPG during follow-up. Furthermore, it is possible that the hemodynamic benefits of this valve may become even more obvious with a larger population of patients and a longer follow-up period. The incidence of PPM with an EOA index threshold <0.85 cm2/m2 (based on manufacturer-provided EOA data) was significantly higher in the Perimount group than in the Magna group. Despite this, the former exhibited improved overall and event-free survival rates (14,19). We have already reported that 19-mm Perimount valves led to favourable AVR clinical outcomes (13). The relationship between AVPG and long-term outcomes needs further investigation.

Given the retrospective nature of this study, our results should be interpreted with some caution. Magna valves have been used for AVR since 2005 at Samsung Medical Center. The Magna valve was the most popular replacement for its predecessor, the Perimount valve. Since March of 2017, we have used the next version of the Magna—Perimount Magna Ease valves. One study compared the Perimount, Magna, and Perimount Magna Ease valves and reported slightly improved outcomes with the first versus the other two (20). However, the study size used to obtain these results was small. We therefore cautiously conclude that there is no clear evidence that Magna valves are superior to Perimount valves in terms of their long-term clinical outcomes. Further studies with larger numbers of patients are needed, however, to validate these findings.


While this study offers some significant benefits to the field, it is limited by its retrospective design and relatively small sample size. Also, the groups were not well balanced in terms of the number of participants included in each. Furthermore, we were unable to analyse aortic root size (sinotubular junction, sinus of Valsalva, or aortic valve annulus) or coronary artery orifice height due to missing data. Additional risk factors might have been identified had these variables been analysed. Furthermore, postoperative EOA values measured via echocardiography were unavailable. To address this limitation, we attempted to evaluate hemodynamic performance via echocardiographically measured AVPGs. A further limitation is that the Perimount and Magna valves assessed here were implanted for different periods of time with 4–5 years of overlap. Therefore, various changes in other domains of our clinical practice during the study period, many of which are unmeasurable, may have occurred. Additionally, operations performed more recently may have benefitted from improved perioperative care. However, the improvements in outcomes with Perimount valve use [1998–2005] appeared to be substantial beyond mitigation by these limitations.

To summarize, evidence should be firmly presented when we are to confirm new generation valves are better. Best implantation techniques can be an important factor to long-term clinical outcomes.


We wish to thank research assistant Joomin Hwang, who helped with data collection and management. We also wish to thank medical illustrator SeMin Oh for assistance with figure creation.


Conflicts of Interest: The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The hospital institutional review board of Samsung Medical Center approved this study and waived any need for informed consent due to its retrospective nature (no. 2018-01-013).


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Cite this article as: Chang HW, Kim WS, Ahn JH, Carriere KC, Jeong DS, Cho YH, Sung K, Park PW. Late clinical outcomes of aortic valve replacement with Carpentier-Edwards pericardial valves. J Thorac Dis 2019;11(12):5372-5381. doi: 10.21037/jtd.2019.11.65

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