Evaluation of local aggressive lung therapy versus systemic therapy in oligometastatic non-small cell lung cancer: a systematic review and meta-analysis
Introduction
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths around world, about 40% of them are stage IV at diagnosis (1). Systemic therapies (ST) are recommended for these patients (2). However, few patients survived more than 5 years though with the remarkable development of targeted therapy and immunotherapy (3).
Oligometastases is an intermediate state between localized and disseminated cancer proposed by Hellman and Weichselbaum (4). Approximately 25% of stage IV NSCLC patients present with oligometastases (5). A series of cohort studies (6-8) and several randomized controlled trials (RCT) (9-11) showed the effectiveness of local aggressive thoracic therapy (LT) including radiotherapy (RT) and surgery on prolonging survival compared with systemic therapy for oligometastatic NSCLC patients. Nonetheless, due to the restrict recruitment and heterogeneity of stage IV disease, these studies were with small sample size and not long enough follow-up time.
To further explore the current situation and effectiveness of local aggressive thoracic therapy for oligometastatic NSCLC, it is important to make a pooled analysis and provide more information for future design.
We present the following article in accordance with the PRISMA reporting checklist (available at https://dx.doi.org/10.21037/jtd-21-957).
Methods
Protocol of present study was registered on PROSPERO as number: CRD42021233095.
Searching strategy
PubMed, Embase and Web of knowledge were searched from January 2001 to December 2020 by two reviewers (Chenxi Zhang and Nan Ma). Searching strategy was displayed as Table S1.
Study selection
Two reviewers screened studies according to pre-specified criteria independently. Consensus was discussed by two reviewers and another researcher (Qitong Zhang).
Present study was designed to enroll oligometastatic NSCLC as 1–5 metastatic lesions regardless of organs (9,10,12). LT was defined as surgery, stereotactic body radiotherapy with >20 Gy, beam radiotherapy with dose >45 Gy combined with or without ST. ST included chemotherapy, targeted therapy and immunotherapy. Palliative radiotherapy was permitted in systemic cohort with intent to relief symptoms and dose lower than local therapy cohort.
Studies meet the following criteria were included: (I) RCT or cohort studies comparing the effectiveness of local aggressive thoracic therapy and systemic therapy for oligometastatic NSCLC patients; (II) Hazard ratio of death or disease-progression could be retrieved; (III) Kaplan-Meier curve of overall or progression-free survival was reported. The exclusion criteria were as follow: (I) small cell lung cancer; (II) study with less than 10 cases; (III) palliative RT in systemic group with no clear statement of dose and intent; (IV) unbalanced local treatment for metastases, such as a cohort of lung LT treated patients compared with a cohort of lung ST but metastases LT treated patients.
Data extraction and risk of bias
All data were extracted by two independent reviewers. First author, year of publication, study type, sample size, eligible criteria, clinical characteristics of patients, treatment strategy, median overall survival time (OS), median progression-free survival time (PFS), hazard ratios (HR) and number of adverse events were retrieved from original studies as reported. HR could be estimated by data extraction of Kaplan-Meier curve (13), if not mentioned. Pooled survival time and survival curve were generated by methods reported (14).
Cochrane risk table was used to evaluate the bias of RCT. Newcastle-Ottawa scale was used for assessing cohort studies, and 6 or more points were considered as high quality.
Statistical analysis
The primary endpoint was OS, second endpoints were PFS and adverse effects. The calculation of HR was performed by Revman (Version 5.4, The Cochrane Collaboration, http://ims.cochrane.org/revman). Statistical analysis was made under fixed effect model, other than random effect model with considerable heterogeneity. I2>25% was regarded as mediate heterogeneity, and >50% as considerable heterogeneity. Sensitivity analysis was performed by enrolling RCT and high quality cohort studies. A P value below 0.05 was considered as statistical difference.
Data extraction of Kaplan-Meier survival curve was performed by “Engauge Digitizer” (Version 12.1, http://digitizer.sourceforge.net). Linear regression and pooled survival was performed by R software (Version 4.0.3, r-project, http://www.r-project.org). R package “MetaSurvival” (Version 0.1.0, http://github.com/shubhrampandey/metaSurvival) was used to calculated cumulative survival rate and package “ggplot2” (Version 3.3.3, http://ggplot2.tidyverse.org) was used to generate regression and survival curve.
Results
Searching results
Totally 12,220 articles were screened based on searching strategy, and 5,563 duplicates were excluded and 6,599 were exclude after reviewing title and abstract. By assessing full-text and further study, 8 articles were retrieved for final analysis. The selection procedure was displayed as Figure 1.
Baseline characteristics and risk assessment
Totally 3 RCT (9,10,12) (2 published studies and 1 conference abstract) and 5 retrospective cohort studies (RCS) (15-19) (all published) were included. For study type, 6 studies were single center analysis and 2 were multicenter. All patients were selected based on histologically proven NSCLC. Performance score (KPS ≥70 or ECOG ≤2) were the most common criteria for recruitment of patients (in 6 studies). With regard to definition of oligometastases, 1 study proposed that 1 lesion in 1 organ, 1 study proposed 1–4 lesions in 1 organ, 1 study suggested 1–5 lesions in 1 organ and 1 suggested 1–3 lesions (counting positive lymph nodes) regardless of organ. These 4 studies all implemented surgery as component of treatment strategy. The remaining 4 studies using RT as the only way of LT, defined oligometastases as 1–5 lesions ignoring number of organs involved. For systemic therapy, 5 studies were based on chemotherapy only, 1study contained both chemotherapy and targeted therapy and 2 studies used targeted therapy alone. Three studies reported LT for lung only, and 5 studies applied LT for both lung and metastases (Table 1).
Table 1
Study | Period | Type of study | Eligibility | Intervention | LT sites | Outcomes |
---|---|---|---|---|---|---|
Gray 2014 | 2000–2011 | RCS/Single | pNSCLC, 1–4 brain lesions, no extra-cranial metastases, KPS ≥70 | Surgery ± RT: 38 | Lung | OS |
CH ± palliative RT: 28 | ||||||
Xanthopoulos 2015 | 2004–2010 | RCS/Single | pNSCLC, 1–4 lesions regardless of organ, ECOG ≤2 | CH + RT: 25 | Lung | OS, AE |
CH: 50 | ||||||
Johnson 2016 | 2005–2014 | RCS/Single | pNSCLC, 1–5 lesions, single organ, extra-pulmonary | Surgery/RT: 22 | Lung | OS |
CH: 13 | ||||||
Huang 2017 | 2001–2015 | RCS/Single | pNSCLC, single lesion, adrenal metastases | Surgery: 10 | Lung + metastases | OS |
CH: 12 | ||||||
Iyengar 2018 | 2014–2016 | RCT/Single/Phase II | pNSCLC, stable disease after first-line CH, ≤5 extra-brain distant metastases regardless of organs involved, KPS ≥70, TKI naïve, no untreated brain lesion or involving gastrointestinal/skin metastases | CH + SBRT + MCT: 14 | Lung + metastases | PFS, OS, AE, recurrence, metastases |
CH + MCT: 15 | ||||||
Xu 2018 | 2010–2016 | RCS/Single | pNSCLC, EGFR+, ≤5 metastases regardless of organs, ECOG ≤2, stable after first-line EGFR TKI | TKI + Surgery/RT: 51 | Lung + metastases | PFS, OS, AE |
TKI: 39 | ||||||
Gomez 2019 | 2012–2016 | RCT/Multi/ Phase II | pNSCLC, age ≥18, ≤3 lesions regardless of organs, positive LN counted as metastasis, ECOG ≤2, after standard first-line ST, no bevacizumab in 2 weeks | CH/TKI + Surgery/RT + MT: 25 | Lung + metastases | PFS, OS, AE |
CH/TKI + MT: 24 | ||||||
Wang 2020 | 2016–2019 | RCT/Multi/Phase III | pNSCLC, EGFR+, ≤5 metastases, ECOG ≤2, systematic therapy naïve, no brain lesion at randomization | Upfront SRS + TKI: 68 | Lung + metastases | PFS, OS, AE |
TKI: 65 |
RCT, random controlled trials; RCS, retrospective cohort studies; Single, single-center study; Multi, multi-center study; NSCLC, non-small cell lung cancer; ECOG, eastern cooperative oncology group; EGFR, epidermal growth factor receptor; TKI, tyrosine kinase inhibitor; KPS, Karnofsky performance score; CH, chemotherapy; SBRT, stereotactic body radiotherapy; SRS, stereotactic radio-surgery; RT, radiotherapy; MT, maintenance therapy; MCT, maintenance chemotherapy; PFS, progression-free survival; OS, overall survival; AE, adverse events.
Totally 499 patients were included in this analysis, 253 (50.7%) were in LT group and 246 (49.3%) were in ST group. The median age of LT patients ranged from 55 to 63 years, while 58 to 70 years of ST. Four studies enrolling 253 patients presented performance status. Of these patients, 90 (72.6%) patients were with ECOG 0-1 point or KPS ≥80 points in LT group, and corresponding number in ST group was 83 (64.3%) (P=0.159). There were 5 studies enrolling 225 patients reporting proportion of patients with N2–3 positive. Thirty-five (28.7%) and 61 (59.2%) patients were N2–3 positive in LT and ST group (P<0.001), respectively. Totally 6 studies containing 331 patients reported number of patients with single distant lesion. There were 88 (54.0%) patients in LT group and 85 (50.6%) patients in ST group with single distant metastasis (P=0.128). Only 4 studies presented median PFS, and 2 studies were lack of median OS in LT group due to not long enough follow-up time (Table 2, Table S2).
Table 2
Study | Intervention | Patients | Age (median) | Sex (M/F) | ECOG 0-1 KPS ≥80 (%) | cN2–3 (%) | Single distant lesion (%) | Single distant organ (%) | Maximum distant organs | mPFS (months) | mOS (months) |
---|---|---|---|---|---|---|---|---|---|---|---|
Gray 2014 | LT | 38 | 55 | 14/24 | 27 (71.1) | – | 19 (50.0) | 38 (100.0) | 1 | – | 26.4 |
ST | 28 | 60.5 | 10/18 | 16 (57.1) | – | 14 (50.0) | 28 (100.0) | 1 | – | 10.5 | |
Xanthopoulos 2015 | LT | 25 | 59 | 11/14 | 17 (68.0) | – | 13 (52.0) | 17 (68.0) | 4 | – | 22 |
ST | 50 | 58 | 30/20 | 34 (68.0) | – | 23 (46.0) | 34 (68.0) | 3 | – | 9 | |
Johnson 2016 | LT | 22 | 63 | 8/14 | – | 0 (0) | – | 22 (100.0) | 1 | – | NR |
ST | 13 | 65 | 5/8 | – | 13 (100.0) | – | 13 (100.0) | 1 | – | 18.2 | |
Huang 2017 | LT | 10 | Mean 56 | 7/3 | 9 (90.0) | 7 (70.0) | 10 (100.0) | 10 (100.0) | 1 | – | 12 |
ST | 12 | Mean 62 | 9/3 | 5 (41.7) | 12 (100.0) | 12 (100.0) | 12 (100.0) | 1 | – | 9 | |
Iyengar 2018 | LT | 14 | 63.5 | 9/5 | – | 7 (50.0) | 6 (42.8) | 6 (42.9) | 2 | 9.7 | NR |
ST | 15 | 70 | 11/4 | – | 7 (46.6) | 5 (33.3) | 4 (26.7) | 1 | 3.5 | 17 | |
Xu 2018 | LT | 51 | – | 21/30 | 37 (72.5) | 13 (25.5) | 25 (49) | – | – | 20.6 | 40.9 |
ST | 39 | – | 20/19 | 28 (71.8) | 20 (51.3) | 16 (41) | – | – | 13.9 | 30.8 | |
Gomez 2019 | LT | 25 | 63 | 12/13 | – | 8 (32.0) | 15 (60.0) | 22 (88.0) | 2 | 14.2 | 41.2 |
ST | 24 | 61 | 10/14 | – | 9 (37.5) | 15 (62.5) | 21 (87.5) | 2 | 4.4 | 17 | |
Wang 2020 | LT | 68 | – | – | – | – | – | – | – | 20.2 | 25.5 |
ST | 65 | – | – | – | – | – | – | – | 12.5 | 17.4 |
M, male; F, female; ECOG, eastern cooperative oncology group; KPS, Karnofsky performance score; mPFS, median progression-free survival; mOS, median overall survival; LT, local aggressive lung therapy; ST, systemic therapy; NR, not reached.
Among the 3 RCT, all studies were with high risk of binding procedure for the different implementation of LT and ST (Figure S1). For the 5 RCS, 1 study were considered as high quality with 6 points by Newcastle-Ottawa scale assessment (Table S3).
Correlation between survival and clinical characteristics
Linear regression showed that there was no correlation between proportion of patients with single metastatic lesion and survival, both in LT and ST groups (Figure S2). Same results were also presented between proportion of patients with N2–3 positive and corresponding survival in ST group. There was a trend that median OS declined with increasing proportion of N2–3 positive patients in LT group, but with no statistical difference (P=0.09, R2=0.98) (Figure 2).
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/2/articles/55833/public/55833-PB7-3976-R1.jpg/w300)
Cumulative survival and subgroup analysis
LT for oligometastatic NSCLC patients achieved reduction of 47% (HR =0.53, 95% CI: 0.43–0.65) and 59% (HR =0.41, 95% CI: 0.31–0.55) in the risk of death and cancer progression, respectively (Figure 3). No statistical difference was found of heterogeneity in both OS (I2=11%, P=0.35) and PFS (I2=36%, P=0.19). All analysis was performed by fix effect model.
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/2/articles/55833/public/55833-PB8-9499-R1.jpg/w300)
Six studies with applicable Kaplan-Meier curve of OS were enrolled for pooled analysis. The estimated pooled OS rate were 73.6%, 47.0%, 33.1% and 9.1% at the 1, 2, 3 and 5-year in LT group. The corresponding OS rate in ST group were 53.5%, 25.2%, 9.8% and 0%. Median OS of these 2 groups were 21.6 and 14.3 months, separately (Figure 4A).
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/2/articles/55833/public/55833-PB9-4297-R1.jpg/w300)
Three studies with available PFS curve were also pooled. The estimated pooled PFS rate were 56.3%, 18.2%, 2.3% and 0.6% at the 1, 2, 3 and 4-year in LT group. The corresponding PFS rate in ST group were 26.0%, 3.0%, 0.7% and 0%. Median PFS of these 2 groups were 14.0 and 6.5 months, respectively (Figure 4B).
In subgroup analysis, patients undergoing LT with or without surgery both showed benefits compared to those with ST on OS and PFS. Furthermore, patients receiving surgery as component of multi-modality therapy showed a lower HR of 0.33 (95% CI: 0.22–0.48) on PFS compared to 0.55 (95% CI: 0.36–0.83) of these without surgery (Figure 5). For patients receiving consolidative LT (systemic therapy followed by local therapy), HRs were 0.33 (95% CI: 0.23–0.47) and 0.45 (95% CI: 0.34–0.60) on PFS and OS compared to ST ones. For patients receiving upfront LT (local therapy first), HRs were 0.62 (95% CI: 0.39–0.99) and 0.68 (95% CI: 0.47–1.00) compared to ST ones (Figure 6). Besides, studies were divided by study type (RCT and RCS), local treatment sites (LT for lung and LT for both lung and metastases) and systemic regimens (chemotherapy only or with targeted therapy). LT obtained more favorable survival in all subgroups (Figures S3-S5).
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/2/articles/55833/public/55833-PB10-8156-R1.jpg/w300)
![Click on image to zoom](http://cdn.amegroups.cn/journals/pbpc/files/journals/2/articles/55833/public/55833-PB11-8874-R1.jpg/w300)
Adverse effects
There were 3 studies reported grade 3 or higher adverse effects of both LT and ST groups. The odds ratio of LT group was 1.84 (95% CI: 0.79–4.29) compared with ST group, but with no statistical difference (P=0.16) (Figure S6, Table S4).
In addition, 2 studies reported toxicity induced by addition of LT. For about 8–17% of LT treated patients suffered grade 3 or higher pneumonitis and esophagitis (Table S5).
Sensitivity analysis
In sensitivity analysis, 3 RCT and 1 RCS were included. Pooled estimation confirmed the robust and stability of original conclusions (Figure S7).
Discussion
To the best of our knowledge, this is the first meta-analysis enrolling RCT to compare local aggressive thoracic therapy and systemic therapy for patients with oligometastatic NSCLC. LT for oligometastatic NSCLC patients showed more benefits on reducing risk of death and cancer progression than ST. For primary endpoint, the OS was prolonged about 7 months in LT group. For secondary endpoint, LT favored PFS for about 7 months, and with acceptable adverse effects.
Up to now, the definition of oligometastases is still on debate (20). A systematic review analyzed the criteria of oligometastatic NSCLC in publications until now, and no formal definition was established in most of published studies. The upper number of lesion ranges from 1 to 8 with no limitation on organs involved (21). Present study was designed to enroll patients owing 1–5 metastases regardless of orangs which was consistent with majority of randomized controlled trials conducted in recent years (9,10,12). The definition of oligometastases is decided by number of metastatic lesions and the number of metastatic organs. For metastatic lesions, more than 90% oligometastatic NSCLC patients were with 1 metastasis, and nearly 100% patients were with less than 5 metastases (21). In present meta-analysis, 6 studies enrolling 273 patients reported the number metastatic lesions, and approximately 70% were with single metastatic lesion. Single distant metastasis was categorized as M1b, which was considered to have more favorable survival than multiple metastases, in the 8th edition of TNM (tumor, node, and metastasis) classification (22). However, in the present study, proportion of single distant metastatic patient not impact the survival of studies included. Further subgroup analysis for patients with single metastasis between local therapy and systemic therapy could not be made for the lack of survival data in this subgroup. For metastatic organs, 5 studies enrolled in this study showed the maximum organs actually involved. Four of these five studies enrolled patients with no more than 2 organs involved. A more conservative definition of oligometastases (single organ) was used if surgery was taken as component of local therapy (10,15,17,18). A pan-European consensus reported a proposal of 1–5 metastatic lesions in no more than 3 organs may be an appropriate definition for oligometastases (23).
Positive mediastinal lymph node might be a contradictory for LT (17,18). Several studies excluding N2 positive oligometastatic NSCLC patients from lung resection treatment due to possible detrimental survival (17,24), Presence of mediastinal lymph nodes metastases indicated worse survival, and high proportion of N2 positive patients might result in a negative effect of lung resection on oligometastatic NSCLC patients (18,25). However, same results were not reproduced when applying radiotherapy as non-invasive local treatment strategy (9,16,26). Our linear regression analysis showed that OS of LT patients was decreased with the increasing proportion of N2–3 positive patients, though with no statistical difference. However, none of included studies compared survival between LT and ST patients in N2–3 positive subgroup. A consensus report proposed that mediastinal lymph nodes metastases was of importance in determining whether LT applied for oligometastatic NSCLC patients (23), and it should be further investigated in the future.
Good performance score is important for patient selection. Van den Begin and colleagues constructed a tool to select oligometastatic NSCLC patients for LT, and KPS performance score took the leading position to predict survival (27). In the present, 6 studies proposed ECOG ≤2 or KPS ≥70 as eligibility. Three RCT studies did not report the number of patients in each performance status point, but were designed with balanced recruitment of baseline characteristics. Four retrospective studies presented more than 70% of patients owing ECOG 0-1 point or KPS ≥80 points in LT group, but with no statistical difference compared with ST group (P=0.159). In addition, median ages of LT patients seemed slightly younger than ST ones (53–63 vs. 58–70). Younger patients may own better general condition to tolerate toxicity of LT, and it might be one of the reason that better survival was achieved in LT group.
Surgery and radiotherapy are both suitable choice for oligometastatic NSCLC patients. Previous study systematically reviewed LT for oligometastatic NSCLC regardless of surgery or radiotherapy, no significant difference of OS was found between these 2 approaches (21). In present study, both surgery and radiotherapy could obtain survival benefits compared with ST in subgroup analysis. However, a lower HR of 0.33 (95% CI: 0.22–0.48) on PFS was observed in studies including surgery as component of LT compared to 0.55 (95% CI: 0.36–0.83) of those without surgery. Therefore, surgery still took an important role in LT application for oligometastatic NSCLC patients under suitable selection. It was worth noting that several studies enrolling N3 positive patients included surgery as local therapy, but presented scarce information of whether surgery was performed on these patients. For patients with N3 positive status, radiotherapy for lung is recommended rather than surgery (2). Besides, clinical information and survival data of surgery and radiotherapy could not be retrieved from original study separately. A comparison between these two groups could not be achieved. Thus, the superiority comparison of surgery and radiotherapy for oligometastatic NSCLC should be explored by head-to-head study.
The sequence of LT and ST intervention is another key point for treatment strategy of oligometastatic NSCLC patients. Systemic therapy first could diminish tumor lesion to the maximum extent or screen out disease resistant to ST for recruiting suitable patients for further LT to avoid unnecessary injury or adverse events (7). However, delayed LT intervention might miss the opportunity of curative intent tumor elimination. On the contrary, removing tumor lesions directly could reduce tumor burden immediately to set the scene of following systemic therapy (26). Nevertheless, it may lead to unsuitable selection of patients with diffused cancer which are not detected yet. From this study, LT after first-line ST might be more beneficial for survival. There were three studies implement consolidative LT after first-line systemic therapy resulted an HR of 0.45 (95% CI: 0.34–0.60) for OS compared with ST. It was also presented in the study conducted by Jones and colleagues that neo-adjuvant therapy resulting survival benefits for lung resected oligometastatic NSCLC patients (25). Only one study underwent LT before systemic therapy with an HR of 0.68, and the upper interval was 1.00 (95% CI: 0.47–1.00). For its interim analysis nature, the survival advantage of upfront LT should be re-evaluated during the follow-up.
As to adverse effects, LT group showed a trend of more adverse events compared to ST group (HR =1.84, 95% CI: 0.79–4.29), but with no statistical difference (P=0.16). Pneumonitis and esophagitis are most common adverse event of radiotherapy for about 8–17% patients (16,19). Surgery related complications were reported as 9% in our center for stage IV NSCLC patients (28). This reminds us that candidates for LT should be with tolerance of toxicity after proper selection.
This study also has several limitations. Primarily, the study enrolled not only randomized controlled trials, but also retrospective cohort studies, for the scarcity of publications. Inherent biases existed in these retrospective studies, like unbalanced patients baseline characteristics between local therapy and systemic therapy groups. There were more N2–3 positive in systemic therapy cohort and more probable younger patients in local therapy cohort. More randomized controlled trials should be conducted and data of this meta-analysis should be updated in the future. Besides, due to the heterogeneity of stage IV NSCLC, such as patients with different metastatic sites, the results of pooled analysis should be interpreted cautiously. Furthermore, for the lack of individual patient data and subgroup analysis in original report, further and detailed analysis could not be achieved. For instance, survival benefits of local therapy in N2–3 positive, single distant metastasis and surgically treated subgroup of patients. Last but not least, radiotherapy combined with immunotherapy also showed expecting effectiveness for oligometastatic NSCLC patients, but not included in present study due to its lack of survival data.
In conclusion, local aggressive thoracic therapy could prolong 7 months overall and progression-free survival compared with systemic therapy in patients with oligometastatic non-small cell lung cancer. Consolidative local therapy might be a more favorable choice of local therapy to offer survival benefits. Benefits of local therapy for N2–3 positive patients should explored further.
Acknowledgments
We would like to thank Wenhao Liu for his help in polishing our paper.
Funding: This work was supported by the Natural Science Foundation of Shaanxi Province [grant number: No. 2016JM8087 to Jinbo Zhao] and the National Natural Science Foundation of China [grant number: 81001041 to Jinbo Zhao and 81572252 to Xiaofei Li].
Footnote
Reporting Checklist: The authors have completed the PRISMA reporting checklist. Available at https://dx.doi.org/10.21037/jtd-21-957
Peer Review File: Available at https://dx.doi.org/10.21037/jtd-21-957
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://dx.doi.org/10.21037/jtd-21-957). JB Zhao reports funding from Natural Science Foundation of Shaanxi Province (2016JM8087) and funding from National Natural Science Foundation of China (81001041). XF Li reports funding from National Natural Science Foundation of China (81572252). The other authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
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