AB 20. Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease
Abstract

AB 20. Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease

Paschalis Steiropoulos1, Evangelia Nena2, Maria Xanthoudaki1, Pavlos Zarogoulidis1, Thomais Goula1, Panagiotis Boglou1, Konstantinos Archontogeorgis1, George Zacharis1, Stavros Anevlavis1, Nikolaos Papanas3, Marios Froudarakis1, Demosthenes Bouros1

1Department of Pneumonology, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; 2Laboratory of Hygiene and Environmental Protection, Medical School, Democritus University of Thrace, Alexandroupolis, Greece; 3Outpatient Clinic of Obesity, Diabetes and Metabolism, Second Department of Internal Medicine, Medical School, Democritus University of Thrace, Alexandroupolis, Greece

Background: In patients with COPD, there is an evidence of platelet activation due to chronic hypoxia and systemic inflammation. Aim of the study was to evaluate Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW), markers of platelet activation, in patients with Chronic Obstructive Pulmonary Disease (COPD), and to investigate possible associations with pulmonary function testing [Forced expiratory volume in 1 second (FEV1) and Forced vital capacity (FVC)].
Patients and methods: Current smokers with stable COPD (n=85) and smokers without airflow limitation (n=35) were included. To all of them pulmonary function testing was performed and count of white blood cells (WBC) platelets, as well as MPV and PDW were measured.
Results: In smokers with COPD, MPV was significantly higher (mean value 10.563±1.531 vs. 9.956±1.046 fl, P<0.05) than in control group. WBC was also significantly higher in patients with COPD than in controls (9045.53±2664.34/μL vs. 7018.79±1989.74/μL, P<0.001). A significant correlation between MPV and WBC in COPD patients was revealed, especially in those at GOLD Stage III (r=0.475, P=0.012) and IV (r=0.367, P=0.033). WBC count was correlated with FEV1/FVC values (P=0.044). MPV did not correlate with any indices of COPD severity.
Conclusions: In patients with COPD, MPV and WBC levels are significantly correlated and are elevated in comparison to smokers with normal pulmonary function. WBC count was negatively correlated with FEV1/FVC values.

Cite this abstract as: Steiropoulos P, Nena E, Xanthoudaki M, Zarogoulidis P, Goula T, Boglou P, Archontogeorgis K, Zacharis G, Anevlavis S, Papanas N,Froudarakis M, Bouros D.Mean platelet volume and platelet distribution width in patients with chronic obstructive pulmonary disease. J Thorac Dis 2012;4(S1):AB20. DOI: 10.3978/j.issn.2072-1439.2012.s020

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