AB 56. Combined large cell neuroendocrine CA with squamous cell CA of the lung
Abstract

AB 56. Combined large cell neuroendocrine CA with squamous cell CA of the lung

Argiro Sekouli1, Aggeliki Cheva1, Stavros Tryfon2, Fotis Zoglopitis3, Leonidas Sakkas1

1Department of Pathology, “G. Papanikolaou” General Hospital, Thessaloniki, Greece; 2A’ Department of Pneumonology, “G. Papanikolaou” General Hospital, Thessaloniki, Greece; 3Department of Bronchoscopy, “G. Papanikolaou” General Hospital, Thessaloniki, Greece

Background: Presentation of a rare case of lung neoplasia with review of literature.

Patients and methods: We report a case of a 56-year-old male who underwent total excision of his left lung. An intrabronchal lesion that obstructed the main left bronchus was observed in the lower lobe. The lesion was also infiltrating the lung parenchyma and had maximum dimension 6,5cm. Histological examination revealed a malignant tumor, consisted mostly of large cells with irregular shape, abundant cytoplasm and large nuclei. Immunohistochemical results showed that some of the cells were expressing neuroendocrine markers (chromogranine, synaptophysine, CD 56) and the rest of them were expressing markers (p63, Ck5/6) that defined the presence of a squamous cell carcinoma.

Results: According to morphological and immunohistochemical findings, a diagnosis of a combined large cell neuroendocrine carcinoma with squamous cell carcinoma of the lung was confirmed.

Conclusions: A research in international literature showed that this case of combined large cell neuroendocrine carcinoma with squamous cell carcinoma of the lung is uncommon.

Cite this abstract as: Sekouli A, Cheva A, Tryfon S, Zoglopitis F, Sakkas L. Combined large cell neuroendocrine CA with squamous cell CA of the lung. J Thorac Dis 2012;4(S1):AB56. DOI: 10.3978/j.issn.2072-1439.2012.s056

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