Hypoxia-preconditioned allogeneic mesenchymal stem cells can be used for myocardial repair in non-human primates

Although advances in pharmacotherapy and interventional cardiology have greatly reduced the mortality and morbidity following myocardial infarction (MI), there remains an ongoing need for innovative cell transplantation techniques that can reverse cardiac ventricular remodeling post-MI. Despite the barriers facing the application of cell-based interventions (1,2), a growing number of preclinical studies and clinical trials have demonstrated the safety of a variety of adult stem cell types. Mesenchymal stem cells (MSCs) are one of the most well-studied cell types used in regenerative medicine (3).