Responsiveness to leukotriene D₄ and methacholine for predicting efficacy of montelukast in asthma

A lower responsiveness to leukotriene D4 (LTD₄) or higher LTD₄/[methacholine (MCh)] potency ratio might suggest preferable outcomes of short-term montelukast monotherapy in terms of airway inflammation and lung function in asthmatic patients.