Commentary


Efficacy of crizotinib in ALK fusion variants

Tetsu Kobayashi, Hajime Fujimoto, Esteban C. Gabazza

Abstract

In 1995, rearrangement of the anaplastic lymphoma kinase (ALK) gene was first reported as a fusion gene in anaplastic large cell non-Hodgkin lymphoma, and in 2005 it was again on focus when Mano et al. reported that echinoderm microtubule-associated protein-like4 (EML4)-ALK fusion gene is a powerful oncogene in lung cancer (1,2).

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