The kinome pathways in radioresistance breast cancer stem cells

Radiotherapy (RT) has been considered as a key part in treatment of breast cancer patients, and is an obligatory for those undergo conservative surgery which could decrease the local recurrence rate. However, for those patients who still relapse, the exact mechanism behind radioresistance is still largely unrevealed. In this current article, Guo et al. and his colleges have been developed an approach for profiling the global kinome to give better understanding of the expression pattern of the human kinases in cells and tissues (1).