Original Article


Expression of YTHDF1 and YTHDF2 in lung squamous cell carcinoma and their correlation with PD-L1

Liting Cai, Honglan Qu, Kai Feng, Huizhen He, Fengyun Wang

Abstract

To investigate the expression levels and clinical significance of YTH N6-methyladenosine RNA-binding protein 1 (YTHDF1) and YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2) in lung squamous cell carcinoma (LUSC) tissues, and to preliminarily demonstrate that YTHDF1 promotes the expression of programmed death-ligand 1 (PD-L1) through N6-methyladenosine (m6A) RNA modification.

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