Adenocarcinoma in pure ground glass nodules: histological evidence of invasion and open debate on optimal management

Lung nodules are among the most common findings associated with lung cancer. Computed tomography (CT) is the diagnostic test with the highest sensitivity for lung nodules, with wide range of size and density. Yet the specificity of CT is low in dichotomizing malignant from benign nodules, especially on the basis of a single time-point (1).