Insight into the regulatory mechanism of VEGFA isoforms in p53 mutant breast cancer: can it be substantiated with solely in vitro studies?

Breast cancer is now the leading type of cancer in women, and it’s the primary form of cancer-related death. Five different subtypes of breast cancer have been identified according to some molecular profiling studies. They are normal breast-like, basal-like, luminal A, luminal B, and ERBB2+ breast cancer respectively (1). The investigation and application of neoadjuvant and potential treatment targets in breast cancer have been popular in recent years, as well as the signaling pathways and molecular mechanism exploration in the development of breast cancer.