A very early stage of obstructive fibrinous tracheal pseudo-membrane
formation
1Anaesthesia Unit, S. Croce e Carle Hospital, Cuneo, Italy; 2Thoracic Surgery Unit, S. Croce e Carle Hospital, Cuneo, Italy
Case Report
A very early stage of obstructive fibrinous tracheal pseudo-membrane
formation
1Anaesthesia Unit, S. Croce e Carle Hospital, Cuneo, Italy; 2Thoracic Surgery Unit, S. Croce e Carle Hospital, Cuneo, Italy
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Abstract
As result of a short-term intubation (24 hours), we report a rare and poorly known complication: the formation of an
obstructive fibrinous tracheal pseudo-membrane (OFTP). The diagnosis and therapy of OFTP were due to its spontaneous
expectoration after a long asymptomatic time post extubation (four days): This is a very unusual event. A CT-scan of the
chest performed 3 hours after intubation revealed the first step of pseudo-membrane developing.
Key words
Obstructive fibrinous tracheal membrane; endotracheal intubation complications
J Thorac Dis 2012;4(3):320-322. DOI: 10.3978/j.issn.2072-1439.2012.05.10 |
Introduction
Obstructive fibrinous tracheal pseudo-membrane (OFTP) is an
uncommon and potentially lethal complication seldom seen after
endotracheal intubation. OFTP is usually located on the tracheal
cuff and sometimes it is difficult to distinguish it from other
retained secretions in recently intubated and extubated patients.
The development of this fibrinoid material is not completely
known. However, OFTP requires an urgent management since
causes a life-threatening airway obstruction. Herein, we present a
case of a coughing spontaneous expectoration of OFTP. |
Case report
A 50-year old man was referred to our Emergency Department
after a high-speed street accident. Previous medical history was
irrelevant. On the trauma scene, the patient had been evaluated
by the Anesthesiologist of the Helicopter Emergency Medical
Service with evidence of loss of consciousness (GCS =9) and
lack of airway reflexes that requested an oro-tracheal intubation.
The Anesthesiologist performed the intubation inside the car
with a standard 8-mm cuffed tube; no further details about
intubation had been presented. Therefore, the patient was
referred to our hospital (Emergency Department - level two).
After the standard trauma roentgenograms and the CT-scan
of the brain and the chest, he was discharged to Intensive Care
Unit with diagnosis of left diaphyseal femoral and right kneecap
fractures. He was extubated after 24 hours and maintained in
spontaneous ventilation. On the fourth day after extubation, he
underwent surgical stabilization of fractures. Before induction
of anesthesia, an attempt of nose-gastric tube insertion caused
cough. The patient developed stridor and dyspnea; after few
minutes, he expectorated a thick, annular, whitish cartilaginous
material with improve of respiratory symptoms. A fast flexible
bronchoscopy was performed without evidence of tracheomalacia
or granulation tissue in tracheal wall. Following, the
synthesis of fractures was executed under general anesthesia
without complications. At the end of surgical procedure, the
patient returned to ICU for monitoring. He was extubated the
day after and post-operative course was uneventful. Thirteen
days later a follow-up bronchoscopy revealed a normal tracheal
appearance with C-shape rings of cartilage at regular intervals,
without stenosis or morphological abnormalities of mucosal
surface. Histological examination of the lesion (Figure 1) showed
a pseudo-membrane molding the tracheal wall (maximum
length 5.5 cm, external and internal diameter about 1.5 and 1.0 cm);
microscopic examination presented fibrinous material with
polymorphonuclear infiltration and patchy areas of desquamated
necrotic tracheal epithelium (Figure 2). Cultures of the pseudomembrane
showed no bacterial or fungal growth. The patient
was discharged 23 days after admission.
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Discussion
The OFTP is a rare and poorly understood, potentially fatal
complication associate with the endotracheal intubation.
Neither the real incidence nor the common definition of
this complication is known. Sigrist and colleagues first reported a
description of an OFTP in 1981 (1); the lemma OFTP was proposed
by Deslee (2). A review by Lins and Dobbeleir (3) include, until
April 2010, 23 adult cases. The OFTP is usually located at the
site of the cuff where are removed by bronchoscopy. Clinical
presentation evidence a stridor occurred shortly after extubation
due to partial detachment of proximal part of pseudo-membrane
producing intermittent respiratory failure caused by a valvelike
tracheal obstruction. The spontaneous emission of OFTP
has been described only once previously (4). The mechanism of
development of pseudo-membranous material is nowadays not
completely known. Several risk factors have been proposed as
tracheal injury after intubation (5,6), illness (7), infections, caustic
lesions of gastric reflux (8), hyper-pressure of endotracheal cuff,
wrongly use of large tracheal tubes, length of intubation period.
Since the patient described hereby had a difficult intubation
inside his car on the trauma scene, the previous evidences
described in literature suggest that a traumatic and a forceful
intubation may have damaged the tracheal mucosa, triggering the
OFTP formation. The tip’s tube shearing on the tracheal mucosa
due to an excessive head hyperextension, the repeated micromovements
of the tube due to transport and the swallow might
have sustained the development of the pseudo-membrane. The
chest CT-scan performed 3 hours after the intubation, showed
the contact of the tip’s tube (last 3 cm) to the anterior tracheal
wall just below the cuff (about 8 cm from cricoid cartilage), and
the existence of a luminal tighten close to the posterior tracheal
wall and the surface of the tube (Figure 3). It bordered about
one third of the posterior tracheal wall. We became aware of this
tighten only after the OFTP expulsion when we re-evaluated
the CT-scan images: The luminal lesion was the first step of
pseudo-membrane developing. The characteristics of OFTP
and the histological findings (superficial scratch of the mucosa,
thick fibrinous material with polymorphonuclear infiltration and
desquamated necrotic tracheal epithelium) were similar to others
report in literature and suggest that OFTP represents an early stage
of tracheal ischemic damage. As in other reports, the presence of
OFTP can be silent, if the membrane adheres to tracheal wall.
Consequently, our patient remained asymptomatic for 4 days after
extubation; cough reflex caused by nose-gastric tube insertion
developed the respiratory distress. We speculated that the patient
might have tolerated the OFTP since the analgo-sedation with
morphine concurred to diminish trachea-coughing reflex. The
pseudo-membrane was spontaneously expectorated few minutes
after detach and this is the second report in literature.
Figure 3. CT-scan of the chest performed 3 hours after intubation,
revealed a contact on the tip’s tube to the anterior endo-tracheal
wall just below cuff, and the presence of a luminal narrowing close
the posterior endo-tracheal wall and the lumen surface of the tube.
In conclusion, the inexplicable occurrence of upper way
obstruction with development of respiratory failure in recent
intubation or extubation should lead to contemplate the
presence of OFTP. Our report demonstrates that OFTP can
early develop after intubation and remain silent if there were no
tracheal lumen obstruction. OFTP is certainly underdiagnosed,
as stridor and respiratory failure after extubation are common.
Moreover, reintubation or tracheal suction can remove pseudo
membranous lesions that will remain unknown. Although these
lesions may be life threatening, a careful management results
in favorable outcomes. OFTP requires an immediate diagnosis
by bronchoscopy. OFTP removal through rigid bronchoscopy
remains the gold standard, since the spontaneous expectoration
of OFTP is an outstanding event.
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References
Cite this article as: Manassero A, Ugues S, Bertolaccini L, Bossolasco
M, Terzi A, Coletta G. A very early stage of obstructive fibrinous tracheal
pseudo-membrane formation. J Thorac Dis 2012;4(3):320-322. doi:
10.3978/j.issn.2072-1439.2012.05.10
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