Challenging pulmonary embolism - A new generation of oral anticoagulants

Acute pulmonary embolism (PE) is a relatively common cardiovascular emergency, with an estimated annual incidence of 70 cases per 100,000 individuals (1). Occlusion of the pulmonary arterial bed may lead to acute life-threatening but potentially reversible right ventricular failure, highlighting the need for an early and accurate diagnosis. Initial therapy aims primarily at restoration of flow through occluded pulmonary arteries and the prevention of early recurrences.