Echocardiographic characteristics of paravalvular leak following surgical aortic valve replacement: a retrospective cohort study
Highlight box
Key findings
• This study identified paravalvular leak (PVL) in 8.1% of surgical aortic valve replacement (SAVR) cases, with the majority of cases being mild in severity.
• PVL was most frequently observed at the mid-portion of the right coronary cusp (RCC). Additionally, significant correlations were identified between PVL locations and calcification sites in the preprocedural aortic valve.
What is known and what is new?
• PVL is a known complication following SAVR. Previous research has primarily focused on its incidence, risk factors, and prognosis; however, few studies have investigated the echocardiographic characteristics of PVL or its relation to the preprocedural aortic valve.
• This study provides new insights into the specific locations and severity of PVL and its association with aortic valve calcification, offering a detailed echocardiographic perspective on PVL following SAVR.
What is the implication, and what should change now?
• The findings suggest that thorough preoperative assessment of calcification sites on the aortic valve may help guide adjustments in surgical approaches to minimize the risk of PVL. Additionally, because PVL severity can evolve postoperatively, clear shared decision-making with patients and close postoperative follow-up are essential.
• Larger multicenter studies are recommended to validate these findings and refine effective clinical strategies for PVL detection and management following SAVR.
Introduction
Paravalvular leak (PVL) is a known complication associated with surgical aortic valve replacement (SAVR). The incidence of PVL has been reported to range between 1% and 10% (1,2). The clinical presentation of PVL varies widely among patients. Those with insignificant PVL remain asymptomatic and can be managed with careful monitoring and follow-up (3). In contrast, patients with significant PVL often experience critical symptoms, including heart failure and hemolysis (4,5). These severe manifestations of PVL require urgent medical attention and intervention, underscoring the importance of early detection, effective management strategies, and a thorough understanding of PVL characteristics.
Several reports have been published on PVL following SAVR; however, many focus on prognosis and risk factors (6,7). Reports specifically addressing the inherent nature of PVL itself are limited. Therefore, the primary objective of this study is to elucidate the echocardiographic characteristics of PVL following SAVR while investigating the potential correlation with preprocedural aortic valve characteristics. We present this article in accordance with the STROBE reporting checklist (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2024-1989/rc).
Methods
This single-center retrospective cohort study was conducted at a tertiary care university hospital and approved by the Ethics Committee (University of Iowa Institutional Review Board; 202304620) and individual consent for this retrospective analysis was waived. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). All patients who underwent elective or emergency SAVR surgery from June 1, 2010, to October 31, 2022 were included. Among these, patients diagnosed with PVL following SAVR were enrolled for analysis to investigate echocardiographic characteristics. All echocardiographic images were stored in the IntelliSpace Cardiovascular system (Philips Healthcare, Andover, MA, USA). Patients without stored echocardiographic images were excluded from the analysis.
Pathophysiological information regarding the native or prosthetic aortic valve prior to SAVR was analyzed using intraoperative transesophageal echocardiography (TEE) images. Information regarding PVL following SAVR was analyzed using either intraoperative TEE or postoperative transthoracic echocardiography (TTE) images obtained within 1 year after SAVR surgery. All intraoperative TEE images were recorded by a fellowship-trained attending cardiac anesthesiologist assigned to the cardiac surgical case, and all postoperative TTE images were obtained by the cardiology department. When multiple TTEs were available within the 1-year postoperative period, the one farthest from the day of surgery was used for analysis. Intra- and postoperative echocardiographic images were separately reviewed and verified by two attending cardiac anesthesiologists specialized in perioperative echocardiography. If discrepancies arose, a third attending cardiac anesthesiologist specializing in perioperative echocardiography was consulted for final interpretation.
PVL was identified as a high-velocity regurgitant jet originating from the space between the prosthetic valve sewing ring and the aortic valve annulus (6). PVL severity was defined based on the ratio of PVL jet width to left ventricular outflow tract width: <25% as mild, 25–64% as moderate, and ≥65% as severe (8,9). The location of PVL was determined using a short-axis (SAX) view, with native trileaflet aortic valve positions used as a reference for numbering, regardless of whether the actual valves were trileaflet. Position 1 was designated at the commissure between the non-coronary cusp (NCC) and left coronary cusp (LCC), followed clockwise in the TEE by the mid-portion of the LCC as position 2, the commissure between the LCC and right coronary cusp (RCC) as position 3, the mid-portion of the RCC as position 4, the commissure between the RCC and NCC as position 5, and finally, the mid-portion of the NCC as position 6 (Figure 1). The location of calcification was determined using a SAX view. If calcification was observed in more than two locations or was extensive, the area with the most severe calcification was identified as the location. The degree of the calcification was classified as follows: 0, no calcification; 1, mildly calcified (small, isolated spots); 2, moderately calcified (multiple larger spots); and 3, heavily calcified (extensive thickening and calcification of all cusps) (10). In cases where the locations of both PVL and calcification were identified in a SAX view, the correlation between the site of most severe calcification and PVL location was investigated.

Statistical analysis
Continuous variables were presented as medians (interquartile range), and categorical variables as numbers (percentages). Patient characteristics, reviewed from the electronic medical record system (Epic Systems, Verona, WI, USA), were compared between patients with PVL (PVL group) and those without PVL (non-PVL group) using the Mann-Whitney U test or Fisher’s exact test. Correlations between PVL and calcification locations were assessed using Pearson’s method. A P value of <0.05 was considered statistically significant. Statistical analyses were performed using EZR (EZR; Saitama Medical Center, Jichi Medical University, Saitama, Japan), a graphical user interface for R (The R Foundation for Statistical Computing, Vienna, Austria).
Results
During the study period, there were 948 cases involving SAVR, of which 77 cases (8.1%) were identified with PVL intraoperatively and/or within 1 year postoperatively. Among these 77 cases, 10 cases without stored echocardiographic images were excluded from further investigation, resulting in 67 cases of PVL being analyzed (Figure 2).
Table 1 shows the patient characteristics of the PVL and non-PVL groups. Height, gender, and chronic kidney disease were not significantly different between the groups. Compared to the non-PVL group, the PVL group had a younger age {59 [43–71] vs. 65 [56–73] years, P<0.001}, lower weight {83 [71–95] vs. 90 [77–105] kg, P<0.001}, lower body mass index (BMI) [27.8 (24.4–31.9) vs. 30.1 (26.4–34.6) kg/m2, P<0.001], lower body surface area (BSA) [1.95 (1.79–2.12) vs. 2.04 (1.87–2.21) m2, P=0.007], a lower prevalence of diabetes mellitus [9 (13.4%) vs. 242 (27.8%), P=0.01], a higher preoperative ejection fraction (EF) [60% (55–65%) vs. 55% (50–60%), P=0.01], and a higher rate of previous cardiac surgery [15 (22.4%) vs. 112 (12.9%), P=0.04].
Table 1
Demographic data | PVL group (n=67) | Non-PVL group (n=871) | P value |
---|---|---|---|
Age (years) | 59 [43–71] | 65 [56–73] | <0.001 |
Height (cm) | 172 [163–180] | 173 [165–180] | 0.29 |
Weight (kg) | 83 [71–95] | 90 [77–105] | <0.001 |
Body mass index (kg/m2) | 27.8 [24.4–31.9] | 30.1 [26.4–34.6] | <0.001 |
Body surface area (m2) | 1.95 [1.79–2.12] | 2.04 [1.87–2.21] | 0.007 |
Female sex | 20 (29.9) | 250 (28.7) | 0.89 |
Chronic kidney disease | 12 (17.9) | 168 (19.3) | 0.87 |
Diabetes mellitus | 9 (13.4) | 242 (27.8) | 0.01 |
Preoperative ejection function (%) | 60 [55–65] | 55 [50–60]* | 0.01 |
Previous cardiac surgery | 15 (22.4) | 112 (12.9) | 0.04 |
Data are expressed as n (%) or median [interquartile range]. *, two cases in the non-PVL group had no data on ejection fraction; therefore 869 patients were analyzed. PVL, paravalvular leak.
Table 2 shows the characteristics of aortic valves, indications for SAVR, intraoperative variables, type of surgery, and size of the implanted prosthetic valve. Significant differences were observed between the PVL and non-PVL groups in terms of aortic valve type and indication for surgery (P=0.046 and P=0.02, respectively). Compared to the non-PVL group, the PVL group had a higher prevalence of bicuspid and prosthetic aortic valves prior to SAVR, as well as a higher prevalence of infective endocarditis. The PVL group also had longer cardiopulmonary bypass and aortic cross-clamp times than the non-PVL group {177 [136–242] vs. 143 [115–187] minutes, P<0.001; 143 [98–195] vs. 111 [89–149] minutes, P<0.001, respectively}. The type of surgery and the size of the implanted prosthetic valve were not significantly different between the groups.
Table 2
Variables | PVL group (n=67) | Non-PVL group (n=871) | P value |
---|---|---|---|
Types of native aortic valve | 0.046 | ||
Trileaflet aortic valve | 29 (43.3) | 563 (64.6) | |
Bicuspid valve | 28 (41.8) | 260 (29.9) | |
Prosthetic aortic valve | 10 (14.9) | 48 (5.5) | |
Indications for SAVR* | 0.02 | ||
Aortic valve stenosis | 32 (47.8) | 512 (58.8) | |
Aortic valve regurgitation | 10 (14.9) | 148 (17.0) | |
Aortic valve stenosis and regurgitation | 11 (16.4) | 124 (14.2) | |
Infective endocarditis | 14 (20.9) | 76 (8.7) | |
Intraoperative variables | |||
Cardiopulmonary bypass time (minute) | 177 [136–242] | 143 [115–187] | <0.001 |
Aortic cross-clamp time (minute) | 143 [98–195] | 111 [89–149] | <0.001 |
Type of surgery | 0.10 | ||
Isolated SAVR | 39 (58.2) | 409 (47.0) | |
Size of the implanted prosthetic valve | 0.37 | ||
17 mm | 0 (0.0) | 1 (<0.1) | |
19 mm | 3 (4.5) | 67 (7.7) | |
21 mm | 18 (26.9) | 189 (21.7) | |
22 mm | 0 (0.0) | 1 (<0.1) | |
23 mm | 22 (32.8) | 301 (34.6) | |
25 mm | 15 (22.4) | 217 (24.9) | |
26 mm | 1 (1.5) | 0 (0.0) | |
27 mm | 5 (7.5) | 69 (7.9) | |
29 mm | 3 (4.5) | 25 (2.9) | |
31 mm | 0 (0.0) | 1 (<0.1) |
Data are expressed as n (%) or median [IQR]. *, eleven cases in the non-PVL group had no data on indication for surgery; therefore 860 patients were analyzed. PVL, paravalvular leak; SAVR, surgical aortic valve replacement; IQR, interquartile range.
Among the 67 PVL cases analyzed, intraoperative TEE images were available for review in 61 cases. Postoperative TTE images were available for review in 59 cases, with both intra- and postoperative echocardiographic images available in 53 cases. In 22 of these 53 cases, PVL was detected only on intraoperative TEE images, and in 9 cases, PVL was first noted postoperatively on TTE, with no evidence of its presence intraoperatively. PVL was diagnosed both intraoperatively and postoperatively in 22 of these 53 cases. The mean time from SAVR to postoperative TTE was 93 days (range, 35–273 days).
Table 3 shows the echocardiographic characteristics of aortic valves prior to SAVR. Calcification was observed in 38 cases, with mild calcification in 10 cases (14.9%), moderate in 13 cases (19.4%), and severe in 15 cases (22.4%). The most common sites of calcification were the commissure of the NCC and RCC (position 5) and the mid-portion of the NCC (position 6), each observed in 9 cases (23.7%).
Table 3
Echocardiographic characteristics | Values |
---|---|
Degree of calcification (n=67) | |
None | 29 (43.3) |
Mild | 10 (14.9) |
Moderate | 13 (19.4) |
Severe | 15 (22.4) |
Location of calcification (n=38) | |
Position 1 | 4 (10.5) |
Position 2 | 7 (18.4) |
Position 3 | 4 (10.5) |
Position 4 | 5 (13.2) |
Position 5 | 9 (23.7) |
Position 6 | 9 (23.7) |
Data are presented as n (%). Position numbers are represented as adapted clock positions around the native aortic valve anatomy, as shown in Figures 1,3.
Table 4 presents the intra- and postoperative characteristics of PVL identified by echocardiography. The location of PVL was identifiable in a SAX view in 62 cases (92.5%). In 5 cases where PVL was observed in the long-axis view, it was not visible in the SAX view. The most common location was the mid-portion of RCC (position 4) in 22 cases (35.5%), followed by the mid-portion of the LCC (position 2) and NCC (position 6), each observed in 12 cases (19.4%) (Table 4 and Figure 3).
Table 4
Echocardiographic characteristics | Values |
---|---|
Location of paravalvular leak (n=62) | |
Position 1 | 7 (11.3) |
Position 2 | 12 (19.4) |
Position 3 | 2 (3.2) |
Position 4 | 22 (35.5) |
Position 5 | 7 (11.3) |
Position 6 | 12 (19.4) |
Degree of paravalvular leak (n=67) | |
Mild | 58 (86.6) |
Intraoperatively | 47 (70.1) |
Postoperatively | 11 (16.4) |
Moderate | 9 (13.4) |
Intraoperatively | 5 (7.5) |
Postoperatively | 4 (6.0) |
Data are presented as n (%). Position numbers are represented as adapted clock positions around the native aortic valve anatomy, as shown in Figures 1,3.

Of the 67 PVL cases detected intraoperatively and/or postoperatively, severity was mild in 58 cases (86.6%) and moderate in 9 cases (13.4%), with no severe cases. Among the 47 cases with mild intraoperative PVL, 11 underwent immediate intervention during the same surgery. In four of these cases, mild PVL persisted postoperatively. Of the five cases with moderate intraoperative PVL, three underwent immediate intervention; in one case, PVL was reduced to mild postoperatively, and in the other two cases, PVL was undetectable post-intervention. Moderate PVL was identified postoperatively in two cases where no PVL was detected intraoperatively by TEE. In one instance, mild PVL observed intraoperatively without intervention progressed to moderate postoperatively.
Among the 38 cases with a calcified native valve on intraoperative TEE, PVL was identified in 36 cases, showing a significant correlation between calcification location and PVL position (r=0.74, P<0.001) (Figure 4).

No patients underwent reoperation to repair PVL during the follow-up period. Five patients died within 1 year after surgery. Two patients experienced complicated recoveries and died before discharge, with no postoperative PVL. One patient with mild postoperative PVL died 6 months post-surgery due to sudden cardiac arrest of unknown cause. Another patient with mild postoperative PVL died 2 months post-surgery from infection. Lastly, one patient with moderate postoperative PVL died 11 months post-surgery due to acute heart failure, though the relationship with PVL was unclear.
Discussion
This study focused on the echocardiographic characteristics of PVL following SAVR, with PVL observed in 8.1% of cases. The most frequent PVL location was the mid-portion of the RCC, followed by the mid-portions of the NCC and LCC. A significant correlation was observed between the location of preoperative valve calcification and the location of PVL. The majority of PVL cases were classified as mild. Immediate interventions were often successful in reducing or eliminating PVL when detected intraoperatively. Although infrequent, some cases of PVL were first observed postoperatively without evidence of intraoperative PVL.
The incidence of PVL following SAVR in this study was similar to that reported in other studies (1,2,11). Degenerative valve diseases and prolonged cardiopulmonary bypass time have previously been identified as risk factors for PVL (6,7), and the patients in the PVL group in our study resembled those described in prior reports. The higher prevalence of bicuspid aortic valves and infective endocarditis observed in the PVL group could indicate an association with degenerative valve conditions and annular weakness (12-15). Additionally, the cases in the PVL group were likely more complex, as evidenced by the higher rate of redo cardiac surgeries and longer cardiopulmonary bypass and aortic cross-clamp times. Interestingly, the PVL group also had a significantly higher proportion of younger patients, as well as lower BMI, lower BSA, lower rates of diabetes mellitus, and higher preoperative EF. The reasons for these findings remain unclear and warrant further investigations.
It has been reported that PVL following valve replacement surgery tends to occur more frequently at specific locations (4,16). In our study, PVL was most commonly observed in the mid-portion of the RCC, possibly due to the surgical challenges associated with accessing this area during the procedure (17-19). Conversely, in cases with a calcified aortic valve, the location of PVL varied, tending to occur at the most heavily calcified sites. Severe calcification often requires complex techniques, which can impact surgical outcomes (20,21). This complexity, especially when intervention occurs near the aortic valve annulus, may explain the correlation observed in our study between the location of calcification and the occurrence of PVL.
In this study, immediate intervention for intraoperative PVL was performed during the same surgery in 11 cases of mild PVL and in three cases of moderate PVL. Similarly, previous studies have shown that PVL repair surgeries were conducted not only for severe PVL but also for mild PVL (4). This approach likely reflects a balance between the risks involved and the patient’s overall condition on a case-by-case basis. Notably, mild PVL does not significantly affect mid-term prognosis (7,22), whereas patients with severe PVL can present with cardiac failure and hemolysis, impairing functional capacity and long-term survival (4,5,23,24). In the majority of cases in our study, PVL severity was mild and did not require any intervention during the available follow-up period. However, there were two cases where moderate PVL was first noted postoperatively and one case where intraoperative mild PVL worsened to a moderate level postoperatively, indicating that PVL severity can change over time. Therefore, reliance on a single-point echocardiographic examination at a single point is insufficient, and careful monitoring and follow-up are necessary, even if intraoperative PVL is mild or absent.
In recent years, machine learning technologies have shown promise in enhancing diagnostic accuracy and predicting clinical outcomes across various fields, including cardiology and cardiac surgery. In the context of PVL detection and management, machine learning could play a transformative role by automating and enhancing echocardiographic image analysis, potentially identifying subtle features that might elude human interpretation. Advanced image recognition algorithms, particularly those using deep learning, could be trained to detect PVL patterns, assess PVL severity, and predict PVL progression over time based on preoperative and intraoperative imaging characteristics (25,26). In the future, these technologies may provide clinicians with predictive insights into which patients are at higher risk for PVL following SAVR, enabling targeted preoperative planning and intraoperative adjustments (27). Insights from our study could inform the data used to train such models.
Our study uniquely characterizes the features of PVL using echocardiography at two critical time points: during the surgical procedure and within a one-year follow-up postoperatively. Unlike previous studies, which have primarily focused on prognosis and risk factors associated with PVL (6,7), our research offers a novel perspective by providing detailed echocardiographic characteristics of PVL, including its location, severity, correlation with calcified regions, and changes over time. Our findings enrich the existing body of knowledge and have the potential to guide more effective clinical strategies for managing patients with PVL, assisting clinicians in decisions regarding modifications to surgical techniques, refinements, and the necessity and timing of interventions. Future prospective studies are needed to refine effective methods for PVL detection and management following SAVR.
This study has several limitations that warrant consideration. First, it is a retrospective cohort study and therefore subject to inherent methodological constraints. However, because PVL is relatively rare, conducting a prospective study would be challenging. Second, the retrospective design limited the availability and quality of echocardiographic images, which may have affected data accuracy. To mitigate this, all echocardiographic findings were independently reviewed by two expert echocardiographers to enhance reliability. Third, postoperative TTE follow-up was limited to 1 year, precluding the assessment of long-term changes in PVL following SAVR. Fourth, this study included patients with both trileaflet and bicuspid aortic valves, as well as various etiologies of aortic valve disease, which may have introduced heterogeneity. However, because PVL is relatively rare, restricting the study population solely to one specific aortic valve pathology would have reduced the sample size and limited our ability to investigate key echocardiographic characteristics. Nevertheless, by including all patients with PVL, we aimed to better reflect real-world clinical scenarios and capture a broader range of surgical and anatomical challenges that can lead to PVL. We acknowledge that dedicated prospective or multi-institutional studies focusing on more homogeneous patient subsets—such as isolated trileaflet degenerative aortic stenosis—could yield more nuanced findings regarding PVL incidence, location, and severity. Finally, this study was conducted at a single center with a limited sample size, and the findings may not fully reflect variations across different institutions. Therefore, larger, multicenter studies are recommended to enable a more comprehensive analysis and improve the generalizability of the results.
Conclusions
PVL following SAVR occurred in 8.1% of cases, most frequently in the mid-portion of the RCC, followed by the mid-portions of the NCC and LCC. Additionally, a significant correlation was observed between calcification location and PVL. The majority of PVL cases were mild; however, severity could change over the one-year follow-up period, even in cases where PVL was initially undetected intraoperatively.
Acknowledgments
None.
Footnote
Reporting Checklist: The authors have completed the STROBE reporting checklist. Available at https://jtd.amegroups.com/article/view/10.21037/jtd-2024-1989/rc
Data Sharing Statement: Available at https://jtd.amegroups.com/article/view/10.21037/jtd-2024-1989/dss
Peer Review File: Available at https://jtd.amegroups.com/article/view/10.21037/jtd-2024-1989/prf
Funding: Research reported in this publication was supported by
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://jtd.amegroups.com/article/view/10.21037/jtd-2024-1989/coif). The authors have no conflicts of interest to declare.
Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). The study was approved by the University of Iowa Institutional Review Board (No. #202304620) and individual consent for this retrospective analysis was waived.
Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
References
- Jolliffe J, Moten S, Tripathy A, et al. Perceval valve intermediate outcomes: a systematic review and meta-analysis at 5-year follow-up. J Cardiothorac Surg 2023;18:129. [Crossref] [PubMed]
- Hammermeister K, Sethi GK, Henderson WG, et al. Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial. J Am Coll Cardiol 2000;36:1152-8. [Crossref] [PubMed]
- García E, Sandoval J, Unzue L, et al. Paravalvular leaks: mechanisms, diagnosis and management. EuroIntervention 2012;8 Suppl Q:Q41-52.
- Bouhout I, Mazine A, Ghoneim A, et al. Long-term results after surgical treatment of paravalvular leak in the aortic and mitral position. J Thorac Cardiovasc Surg 2016;151:1260-6.e1. [Crossref] [PubMed]
- Kliger C, Eiros R, Isasti G, et al. Review of surgical prosthetic paravalvular leaks: diagnosis and catheter-based closure. Eur Heart J 2013;34:638-49. [Crossref] [PubMed]
- Wąsowicz M, Meineri M, Djaiani G, et al. Early complications and immediate postoperative outcomes of paravalvular leaks after valve replacement surgery. J Cardiothorac Vasc Anesth 2011;25:610-4. [Crossref] [PubMed]
- O'Rourke DJ, Palac RT, Malenka DJ, et al. Outcome of mild periprosthetic regurgitation detected by intraoperative transesophageal echocardiography. J Am Coll Cardiol 2001;38:163-6. [Crossref] [PubMed]
- Zoghbi WA, Chambers JB, Dumesnil JG, et al. Recommendations for evaluation of prosthetic valves with echocardiography and doppler ultrasound: a report From the American Society of Echocardiography's Guidelines and Standards Committee and the Task Force on Prosthetic Valves, developed in conjunction with the American College of Cardiology Cardiovascular Imaging Committee, Cardiac Imaging Committee of the American Heart Association, the European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography and the Canadian Society of Echocardiography, endorsed by the American College of Cardiology Foundation, American Heart Association, European Association of Echocardiography, a registered branch of the European Society of Cardiology, the Japanese Society of Echocardiography, and Canadian Society of Echocardiography. J Am Soc Echocardiogr 2009;22:975-1014; quiz 1082-4. [Crossref] [PubMed]
- Zoghbi WA, Enriquez-Sarano M, Foster E, et al. Recommendations for evaluation of the severity of native valvular regurgitation with two-dimensional and Doppler echocardiography. J Am Soc Echocardiogr 2003;16:777-802. [Crossref] [PubMed]
- Rosenhek R, Binder T, Porenta G, et al. Predictors of outcome in severe, asymptomatic aortic stenosis. N Engl J Med 2000;343:611-7. [Crossref] [PubMed]
- Aljalloud A, Moza A, Arias JP, et al. Conventional vs. Sutureless Aortic Valve Bioprosthesis: Is Faster Better? J Cardiovasc Dev Dis 2023;10:311. [Crossref] [PubMed]
- Făgărășan A, Gurzu S, Satala CB, et al. The Importance of Aortic Valve Bicuspid Phenotype in Valvular Evolution in Pediatric Patients: A Case Report and Literature Mini-Review. Int J Mol Sci 2023;24:14027. [Crossref] [PubMed]
- Niaz T, Poterucha JT, Johnson JN, et al. Incidence, morphology, and progression of bicuspid aortic valve in pediatric and young adult subjects with coexisting congenital heart defects. Congenit Heart Dis 2017;12:261-9. [Crossref] [PubMed]
- Cotts TB, Salciccioli KB, Swanson SK, et al. Aortopathy in Congenital Heart Disease. Cardiol Clin 2020;38:325-36. [Crossref] [PubMed]
- Naser JA, Hemu MR, Pellikka PA. Considerations in caseous calcification of the mitral annulus: a case report. Eur Heart J Case Rep 2022;6:ytac442. [Crossref] [PubMed]
- Mangi AA, Torchiana DF. A technique for repair of mitral paravalvular leak. J Thorac Cardiovasc Surg 2004;128:771-2. [Crossref] [PubMed]
- Chang Y, Guo H, Qian X, et al. A case report of aortic root repair using a pericardial autograft for type A aortic dissection. J Cardiothorac Surg 2020;15:319. [Crossref] [PubMed]
- Tsuji S, Shimada S, Itoda Y, et al. Aortic valve replacement of a quadricuspid aortic valve with right coronary artery ostium adjacent to one of the commissures. J Cardiothorac Surg 2022;17:146. [Crossref] [PubMed]
- Totsugawa T, Hiraoka A, Tamura K, et al. Easy Placement of Annular Sutures During Minimally Invasive Aortic Valve Replacement. Innovations (Phila) 2017;12:227-9. [Crossref] [PubMed]
- Milhorini Pio S, Bax J, Delgado V. How valvular calcification can affect the outcomes of transcatheter aortic valve implantation. Expert Rev Med Devices 2020;17:773-84. [Crossref] [PubMed]
- Zhang B, Salaun E, Côté N, et al. Association of Bioprosthetic Aortic Valve Leaflet Calcification on Hemodynamic and Clinical Outcomes. J Am Coll Cardiol 2020;76:1737-48. [Crossref] [PubMed]
- Rallidis LS, Moyssakis IE, Ikonomidis I, et al. Natural history of early aortic paraprosthetic regurgitation: a five-year follow-up. Am Heart J 1999;138:351-7. [Crossref] [PubMed]
- Genoni M, Franzen D, Vogt P, et al. Paravalvular leakage after mitral valve replacement: improved long-term survival with aggressive surgery? Eur J Cardiothorac Surg 2000;17:14-9. [Crossref] [PubMed]
- Taramasso M, Maisano F, Denti P, et al. Surgical treatment of paravalvular leak: Long-term results in a single-center experience (up to 14 years). J Thorac Cardiovasc Surg 2015;149:1270-5. [Crossref] [PubMed]
- Yang F, Chen X, Lin X, et al. Automated Analysis of Doppler Echocardiographic Videos as a Screening Tool for Valvular Heart Diseases. JACC Cardiovasc Imaging 2022;15:551-63. [Crossref] [PubMed]
- Wessler BS, Huang Z, Long GM Jr, et al. Automated Detection of Aortic Stenosis Using Machine Learning. J Am Soc Echocardiogr 2023;36:411-20. [Crossref] [PubMed]
- Anand V, Hu H, Weston AD, et al. Machine learning-based risk stratification for mortality in patients with severe aortic regurgitation. Eur Heart J Digit Health 2023;4:188-95. [Crossref] [PubMed]